Evidence map›Paper›PMID 42486103›Full record

ArticleCell reports methods2026

Efficient generation of human cDC1-like cells to detect and enhance tumor-reactive T cells via CD4

Yizhi Wang, Xin Lei, Tom de Wit, Ellen Schrama, Marij J P Welters, Karel van Leeuwen, Sander de Kivit, Miriam de Boer, Jitske van den Bulk, Noel F C C de Miranda and 4 more

Abstract read
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In one paragraph

Article in Cell reports methods, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yizhi WangDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Xin LeiDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands; Oncode Institute, Utrecht, the Netherlands.
Tom de WitDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Ellen SchramaDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Marij J P WeltersDepartment of Medical Oncology, Leiden University Medical Center, Leiden, the Netherlands; Oncode Institute, Utrecht, the Netherlands.
Karel van LeeuwenDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Sander de KivitDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands; Oncode Institute, Utrecht, the Netherlands.
Miriam de BoerDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Jitske van den BulkDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Noel F C C de MirandaDepartment of Pathology, Leiden University Medical Center, Leiden, the Netherlands.
Ton N SchumacherDepartment of Molecular Oncology and Immunology, the Netherlands Cancer Institute, Amsterdam, the Netherlands; Oncode Institute, Utrecht, the Netherlands.
Chong SunImmune Regulation in Cancer, German Cancer Research Center, Heidelberg, Germany.
Jannie BorstDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands; Oncode Institute, Utrecht, the Netherlands.
Yanling XiaoDepartment of Immunology, Leiden University Medical Center, Leiden, the Netherlands. Electronic address: y.xiao@lumc.nl.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Classical type 1 dendritic cells (cDC1s) are crucial to anti-tumor immunity by cross-presenting tumor antigens and priming cytotoxic CD8

Indexed as

CD4-Positive T-LymphocytesDendritic CellsNeoplasmsAntigens, NeoplasmCD8-Positive T-LymphocytesHumansT-Lymphocytes, CytotoxicAntigens, Neoplasmadoptive cell therapyblood progenitorcDC1-licensingcDC1-like cell generationCP: cancer biologyCP: immunologytumor antigen-specific CTL

Identifiers

PMID42486103
PMCPMC13615486

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.