Evidence map›Paper›PMID 42486444›Full record

ArticleThe Journal of allergy and clinical immunology2026

Inhaled S-nitrosoglutathione in asthma: Airway SCoR2 expression and determinants of human bronchodilator response.

Benjamin Gaston, Laura A Smith, Yi Zhao, Richard T Premont, Fanmuyi Yang, James F Chmiel, Andrew Tilston-Lunel, Homer Twigg, Michael D Davis, Anjum Jafri and 8 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of allergy and clinical immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Benjamin GastonDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind. Electronic address: begaston@iu.edu.
Laura A SmithDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
Yi ZhaoDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Ind.
Richard T PremontDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.
Fanmuyi YangDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
James F ChmielDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
Andrew Tilston-LunelDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
Homer TwiggDepartment of Medicine, Indiana University School of Medicine, Indianapolis, Ind.
Michael D DavisDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
Anjum JafriDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio.
Kristie RossDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio.
Olivia GiddingsDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio.
Thomas M RaffayDepartment of Pediatrics, Case Western Reserve University, Cleveland, Ohio.
Zachary W GrimmettDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Kenzie MahanDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
Nadzeya MarozkinaDepartment of Pediatrics, Riley Hospital for Children and Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, Ind.
James D ReynoldsDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Jonathan S StamlerDepartment of Medicine, Case Western Reserve University School of Medicine, Cleveland, Ohio; Harrington Discovery Institute, University Hospitals Cleveland Medical Center, Cleveland, Ohio.

Funding

S-nitrosylation signaling in asthmaP01HL158507 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI LAHM, TIM · 2021 to 2025
$12.0M
Clinical Centers for the NHLBI's Precision Interventions for Severe and/or Exacerbation Prone Asthma (PrecISE) Network (UG1)UG1HL139126 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2017 to 2022
$2.4M
NHLBI NIH HHS P01 HL158507NHLBI NIH HHS UG1 HL139126
6 · The paper itself

Abstract

backgroundAsthma is characterized by airway inflammation and bronchoconstriction. Recent therapies have addressed inflammation but not bronchoconstriction. S-Nitrosoglutathione (GSNO) is an endogenous smooth muscle relaxant that also affects β

objectiveWe studied the effects of inhaled GSNO (iGSNO) in human asthma.

methodsWe measured the effects and metabolism of iGSNO, with a focus on forced expiratory volume in 1 second, β

resultsiGSNO increased forced expiratory volume in 1 second and β

conclusioniGSNO could represent personalized asthma therapy, augmenting β

Indexed as

denitrosylaseGPCRGSNO Reductasenitric oxideS-nitrosothiolS-nitrosylationβ(2)-adrenergic receptor

Identifiers

PMID42486444
PMCPMC13592330

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.