Evidence mapPaperPMID 42486504Full record

SynthesisEuropean respiratory review : an official journal of the European Respiratory Society2026

Comparative response to pharmacological management of asthma in overweight/obese children

Jose A Castro-Rodriguez, Samantha H Averill, M Isabel Castro-Guevara, Francine M Ducharme

Abstract readSystematic ReviewComparative Study
In one paragraph

Synthesis in European respiratory review : an official journal of the European Respiratory Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jose A Castro-RodriguezDepartment of Pediatric Pulmonology, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile jacastro17@hotmail.com.ORCID https://orcid.org/0000-0002-0708-4281
Samantha H AverillDivision of Pulmonary, Allergy, and Sleep Medicine, Riley Hospital for Children, Indianapolis, IN, USA.ORCID https://orcid.org/0000-0002-2659-7576
M Isabel Castro-GuevaraSchool of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.ORCID https://orcid.org/0009-0000-1746-466X
Francine M DucharmeDepartment of Pediatrics, Faculty of Medicine, University of Montreal, Sainte-Justine University Health Centre, Montreal, QC, Canada.ORCID https://orcid.org/0000-0001-5096-0614

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundObese children with asthma experience higher morbidity than their counterparts; whether different treatments should be considered remains to be clarified.

objectiveTo explore the potential group differences in the treatment response to any asthma medications between overweight/obese and normal/underweight children.

methodsWe systematically reviewed case-control, cohort studies and randomised controlled trials (RCTs) examining treatment effects by weight status, identified in four bibliographic databases from inception until January 2025. A narrative synthesis was presented because a meta-analysis could not be conducted due to methodological issues.

resultsNine studies (one RCT, five

conclusionWhile no firm recommendations could be made regarding potential differential treatment responses, the superiority of ICS monotherapy or step-up therapy compared to other controllers appears lost in overweight/obese children.

Indexed as

Anti-Asthmatic AgentsAsthmaLungPediatric ObesityAdministration, InhalationAdrenal Cortex HormonesAge FactorsChildChild, PreschoolFemaleHumansMaleTreatment Effect HeterogeneityTreatment OutcomeAdrenal Cortex HormonesAnti-Asthmatic Agents

Identifiers

PMID42486504
PMCPMC13389718

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.