Evidence map›Paper›PMID 42486901›Full record

ArticleNature cell biology2026

Mapping mesenchymal diversity in the human small intestine and organoids.

Kelli F Johnson, Xiangning Dong, Yu-Hwai Tsai, Angeline Wu, Sydney G Clark, Abigail Vallie, Sha Huang, Charlie J Childs, Rachel K Zwick, Ian Glass and 3 more

Abstract read
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Kelli F JohnsonDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.ORCID http://orcid.org/0000-0002-2407-2039
Xiangning DongDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.
Yu-Hwai TsaiDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.
Angeline WuDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sydney G ClarkGraduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Abigail VallieGraduate Program in Cellular and Molecular Biology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sha HuangDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.
Charlie J ChildsDepartment of Computational Medicine and Bioinformatics, University of Michigan Medical School, Ann Arbor, MI, USA.
Rachel K ZwickDepartment of Cell Biology, NYU Grossman School of Medicine, New York, NY, USA.ORCID http://orcid.org/0000-0003-2012-5890
Ian GlassDepartment of Pediatrics, Genetic Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-6762-8407
Katherine D WaltonDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA.
Ophir D KleinProgram in Craniofacial Biology and Department of Orofacial Sciences, University of California San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-6254-7082
Jason R SpenceDepartment of Internal Medicine, Division of Gastroenterology, University of Michigan Medical School, Ann Arbor, MI, USA. spencejr@umich.edu.ORCID http://orcid.org/0000-0001-7869-3992

Funding

LABORATORY OF DEVELOPMENTAL BIOLOGYR24HD000836 · NICHD · UNIVERSITY OF WASHINGTON · PI Ian Amos Glass · 1995 to 2026
$16.9M
Consortium on Intestinal Regeneration and Fetal Reversion: from Atlas to TherapyRC2DK140862 · NIDDK · CEDARS-SINAI MEDICAL CENTER · PI SARAH E BLUTT, DARIO BOFFELLI · 2024 to 2026
$6.0M
Niche support of human intestinal stem cellsU01DK103141 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SPENCE, JASON · 2014 to 2023
$3.9M
Mechanisms of Hedgehog Regulation of Intestinal Villus MorphogenesisR01DK121166 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WALTON, KATHERINE DEMPSEY · 2019 to 2023
$1.8M
Interrogating sub-epithelial cell heterogeneity in the developing human intestinal stem cell nicheF32DK138694 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelli Johnson · 2024 to 2026
$234k
NICHD NIH HHS R24 HD000836NIDDK NIH HHS F32 DK138694NIDDK NIH HHS R01 DK121166NIDDK NIH HHS RC2 DK140862NIDDK NIH HHS U01 DK103141U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) 5R24HD000836U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) U01DK103141U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) F32DK138694U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) R01DK121166U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) RC2DK140862U.S. Department of Health & Human Services | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (National Institute of Diabetes & Digestive & Kidney Diseases) U01DK103141
6 · The paper itself

Abstract

The organization of diverse mesenchymal populations during human small intestinal development is critical for tissue architecture and function yet remains poorly defined. Here, to construct a comprehensive, tissue-scale map of the developing human small intestine at single cell resolution, we leveraged single-cell RNA-sequencing data to build a Xenium spatial transcriptomics gene panel covering the cell diversity of the human small intestine. We defined five subpopulations occupying discrete anatomical locations within the lamina propria and submucosa-the subepithelial cells, lamina propria fibroblasts, submucosal fibroblasts, smooth muscle cells and CXCL13

Indexed as

Intestine, SmallMesenchymal Stem CellsMesodermOrganoidsFibroblastsHumansIntestinal MucosaMyocytes, Smooth MusclePluripotent Stem CellsSingle-Cell AnalysisSpatial Transcriptomics

Identifiers

PMID42486901
PMCPMC13457098

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.