Evidence map›Paper›PMID 42486990›Full record

ArticleNature2026

Subnuclear genome compartmentalization controls bivalent chromatin activity.

Sajad Hamid Ahanger, Evan R Semenza, Chujing Zhang, Eugene Gil, Mitchel A Cole, Serena Huei-An Lu, Li Wang, Arnold R Kriegstein, Daniel A Lim

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sajad Hamid Ahanger *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-9531-6221
Evan R Semenza *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3494-6542
Chujing Zhang *Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Eugene GilDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Mitchel A ColeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0708-3542
Serena Huei-An LuDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-0434-8840
Li WangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-9510-6294
Arnold R KriegsteinEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, San Francisco, CA, USA.ORCID http://orcid.org/0000-0001-5742-2990
Daniel A LimDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA. Daniel.Lim@ucsf.edu.ORCID http://orcid.org/0000-0001-7221-3425

Funding

Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8M
Medical Scientist Training Program (T32 NRSA Training Grant)T32GM141323 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Aimee Kao · 2021 to 2026
$10.5M
Restorative practice in repairing harm and promoting safe and inclusive practices in the laboratory.T32GM136547 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Adrian Erlebacher, Anita Sil · 2020 to 2026
$4.5M
Developmental Topology of the Human Cerebral CortexR35NS137344 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ARNOLD KRIEGSTEIN · 2025 to 2026
$2.1M
Understanding the neurodevelopmental role and mechanism of histone demethylase JMJD3R01NS112357 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LIM, DANIEL A · 2020 to 2024
$1.9M
BD FACSAria Fusion Cell SorterS10OD021822 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEE, MICHAEL R. · 2016 to 2016
$573k
BLRD VA I01 BX000252NIDDK NIH HHS P30 DK063720NIGMS NIH HHS T32 GM136547NIGMS NIH HHS T32 GM141323NIH HHS S10 OD021822NINDS NIH HHS R01 NS112357NINDS NIH HHS R35 NS137344
6 · The paper itself

Abstract

The nuclear genome is spatially organized into a three-dimensional architecture by physical association of large chromosomal domains with subnuclear compartments including the nuclear lamina at the radial periphery and nuclear speckles within the nucleoplasm

Indexed as

Cell NucleusChromatinGenome, HumanCerebral CortexChromatin Assembly and DisassemblyHistonesHumansMethylationNeurogenesisNeuronsNuclear LaminaTranscription, GeneticChromatinhistone H3 trimethyl Lys4Histones

Identifiers

PMID42486990
PMCPMC13558055

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.