Evidence map›Paper›PMID 42486993›Full record

ArticleNature structural & molecular biology2026

PLA2G2F suppresses ferroptosis through phospholipid remodeling.

Yingying Hu, Joleen Csuka, Presha Rajbhandari, Penghsuan Huang, Nicholas Carbone, Deguang Liang, Wei Gu, Alban Ordureau, Brent R Stockwell, Xuejun Jiang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature structural & molecular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yingying HuCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0009-0005-4089-2693
Joleen CsukaDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-9014-9196
Presha RajbhandariDepartment of Biological Sciences, Columbia University, New York, NY, USA.
Penghsuan HuangDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI, USA.ORCID http://orcid.org/0000-0002-5058-5399
Nicholas CarboneCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9217-6078
Deguang LiangCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Wei GuHerbert Irving Comprehensive Cancer Center, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-1480-2368
Alban OrdureauCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-4924-8520
Brent R StockwellDepartment of Chemistry, Columbia University, New York, NY, USA.ORCID http://orcid.org/0000-0002-3532-3868
Xuejun JiangCell Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. jiangx@mskcc.org.ORCID http://orcid.org/0000-0002-8670-3828

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ferroptosis is an iron-dependent form of regulated cell death driven by phospholipid peroxidation, and it has emerged as a potential therapeutic vulnerability of cancer. Here we identify the secretory phospholipase PLA2G2F (phospholipase A

Indexed as

FerroptosisGroup II Phospholipases A2PhospholipidsUrinary Bladder NeoplasmsAnimalsCell Line, TumorEndoplasmic ReticulumHumansLipid PeroxidationPPAR gammaSignal TransductionGroup II Phospholipases A2PhospholipidsPPAR gammaPPARG protein, human

Identifiers

PMID42486993
PMCPMC13468115

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.