ArticleJournal of gastroenterology and hepatology2026
Burden of Eosinophilic Esophagitis and Gastroesophageal Reflux Disease in Metabolic Dysfunction-Associated Steatotic Liver Disease: A Comprehensive US Healthcare Analysis.
Article in Journal of gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundEosinophilic esophagitis (EoE) and gastroesophageal reflux disease (GERD) share several risk factors with metabolic dysfunction-associated steatotic liver disease (MASLD). However, the relationship between these conditions remains unclear. This study aimed to investigate the association between MASLD and EoE, as well as GERD and its phenotypes.
methodsWe conducted a population-based study using the TriNetX US Collaborative Network, analyzing adult patients (≥ 18 years) with and without MASLD. Propensity score matching (PSM) (1:1) was performed to adjust for demographics and clinical characteristics. The primary outcome was incident EoE. Secondary outcomes included GERD and its phenotypes such as nonerosive reflux disease (NERD), erosive esophagitis (EE), and Barrett's esophagus (BE).
resultsFollowing PSM, a total of 266 980 patients (18-44 years), 385 138 (45-64 years), and 150 640 (≥ 65 years) were included in the analysis. MASLD was strongly associated with increased odds of EoE across all age groups: 18-44 years (OR = 2.905; 95% CI 2.458-3.434), 45-64 years (OR = 2.423; 95% CI 2.057-2.854), and ≥ 65 years (OR = 2.327; 95% CI 1.606-3.371). Similarly, GERD, NERD, EE, and BE were associated with significantly higher odds among patients with MASLD across all age strata.
conclusionOur findings demonstrate a significant association between MASLD and EoE, as well as increased odds of GERD phenotypes in patients with MASLD. These associations highlight the need for further research to explore shared pathophysiological mechanisms and potential clinical implications.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.