Evidence map›Paper›PMID 42487402›Full record

Trial reportJournal of microbiology and biotechnology2026

Efficacy and Safety of Enzyme-Derived Deer Velvet Extract Supplementation on Adults with Chronic Fatigue: a Randomized, Placebo-Controlled, Double-Blind Trial.

Parivash Jamrasi, Ji-Won Seo, Yunho Sung, Donghyun Kim, Sanghyuk Han, Sowoon Kim, Chaewoon Kim, Xinxing Li, Hyun-Je Park, Aeri Song and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of microbiology and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Parivash JamrasiInstitute on Aging, Seoul National University, Seoul 08826, Republic of Korea.
Ji-Won SeoHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Yunho SungHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Donghyun KimHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Sanghyuk HanHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Sowoon KimHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Chaewoon KimHealth and Exercise Science Laboratory, Department of Physical Education, Seoul National University, Seoul 08826, Republic of Korea.
Xinxing LiInstitute on Aging, Seoul National University, Seoul 08826, Republic of Korea.
Hyun-Je ParkYuhan Care Co., Ltd., Yuhan Care R&D Center, Hwaseong 18469, Republic of Korea.
Aeri SongYuhan Care Co., Ltd., Yuhan Care R&D Center, Hwaseong 18469, Republic of Korea.
Sinhwa BaekYuhan Care Co., Ltd., Yuhan Care R&D Center, Hwaseong 18469, Republic of Korea.
Jeongho JeongYuhan Care Co., Ltd., Yuhan Care R&D Center, Hwaseong 18469, Republic of Korea.
Wook SongInstitute on Aging, Seoul National University, Seoul 08826, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic Fatigue Syndrome (CFS) significantly impairs health-related quality of life in working-age populations, leading many individuals to use nutritional supplements for fatigue management. YC-1101, an enzymatically derived deer velvet extract, has demonstrated anti-fatigue potential in preclinical studies; however, clinical evidence in humans remains limited. This study aimed to evaluate the efficacy and safety of YC-1101 in adults with CFS. In an 8-week randomized controlled trial, 100 patients with CFS were assigned to either the YC-1101 or the placebo group. Subjective fatigue was assessed at baseline, at an interim point, and at the end of the intervention. Fatigue-related blood biomarkers and cardiorespiratory endurance were measured at baseline and postintervention. Compared with placebo, YC-1101 significantly improved Factor 1 (general and physical fatigue) of the Multidimensional Fatigue Inventory (MFI) at weeks 4 and 8, with a significant group-by-time interaction (

Indexed as

DeerDietary SupplementsFatigue Syndrome, ChronicAdultAnimalsBiomarkersDouble-Blind MethodFatigueFemaleHumansMaleMiddle AgedQuality of LifeTreatment OutcomeBiomarkersAnti-fatigueCervus elaphus LChronic fatigue syndromeEnzyme-derived deer velvet extractExercise performance

Identifiers

PMID42487402
PMCPMC13396742

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.