ArticleFrontiers in medicine2026
Composition of and changes in faecal microbiota in children diagnosed with oligoarticular juvenile idiopathic arthritis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: In genetically predisposed individuals, changes in the balance of pro- and anti-inflammatory bacteria in the intestinal microbiota may affect the mucosal immune system and contribute to the development of Juvenile Idiopathic Arthritis (JIA). In this study, we aimed to compare the bacterial composition of the faecal microbiota between children with newly diagnosed, untreated oligoarticular JIA and healthy children, in Türkiye. Materials and methods: This study included 25 healthy children and 25 treatment-naive patients diagnosed with oligoarticular JIA. Targeted sequencing of the bacterial 16S ribosomal RNA (rRNA) gene was performed on the genetic material obtained from stool samples. Results: Diversity analyses revealed that the dominant bacteria were present in similar proportions, and their distributions were similar. The number of rare species differed, and their distributions were heterogeneous. The patient group was found to have a higher abundance of Bacteroidetes and a lower Firmicutes/Bacteroidetes ratio. The relative abundance of Dialister was reduced, while Oscillibacter and Alistipes were increased in the patient group. In the patient group, we noted an increase in the Akkermansiaceae family and in the Catenibacterium, Howardella, Holdemanella, Megasphaera and Akkermansia genera, a decrease in the Clostridiaceae and Lactobacillaceae families and Lactobacillus genera. Conclusion: To the best of our knowledge, our study is the first of its kind conducted on this subject in Türkiye. Given that microbiota composition is influenced by geographical characteristics, our study also contributes to the literature regarding the faecal composition of JIA patients in our country. Funding Scientific Research Projects Unit of Pamukkale University.
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