ArticleFrontiers in endocrinology2026
Combined metabolic-reproductive association and predictive value of AMH and TyG index in PCOS: a single-center retrospective study.
Article in Frontiers in endocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine disorder associated with both reproductive and metabolic dysregulation. While anti-Müllerian hormone (AMH) and the triglyceride-glucose (TyG) index have been independently linked to PCOS, their combined and interactive effects remain unclear. This study aimed primarily to investigate the independent and synergistic associations of AMH and the TyG index with PCOS, and secondarily to evaluate their predictive performance for PCOS risk. Methods: A single-center retrospective cross-sectional study included 628 participants (2020-2024). Clinical, hormonal, and metabolic parameters were assessed. Associations and predictive ability were examined using logistic regression restricted cubic splines (RCS), subgroup analysis, and receiver operating characteristic (ROC) curves. Results: Adjusted analyses confirmed AMH and the TyG index as independent risk factors for PCOS ( Conclusion: Beyond their independent roles, AMH and the TyG index interact synergistically in the pathogenesis of PCOS.
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