ArticleFrontiers in oncology2026
The diagnostic efficacy of venous-phase spectral CT combined with Node-RADS for differentiating enlarged lymph nodes in common solid tumors: a preliminary exploratory study.
Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To investigate the value of combining quantitative parameters from spectral CT with the Node Reporting and Data System 1.0 (Node-RADS) in distinguishing between benign and malignant lymph nodes enlarged due to solid tumors, and to explore a combined multiparametric approach. Methods: We retrospectively analyzed data from patients with primary solid tumors accompanied by lymphadenopathy who underwent venous-phase spectral CT scans with energy-resolved imaging. A total of 243 lymph nodes were included in this study. Based on pathological findings, clinical observations, and CT follow-up, the patients were divided into malignant (n = 124) and benign (n = 119) groups. The groups were compared for general characteristics. For each lymph node, we measured the venous-phase spectral CT parameters, including iodine concentration (IC), normalized iodine concentration (NIC), effective atomic number (Z Results: The malignant and benign groups showed significant differences ( Conclusion: An exploratory approach combining quantitative venous-phase spectral CT (VMI
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