Evidence map›Paper›PMID 42488172›Full record

ArticleJAMIA open2026

Development of a clinical trial knowledge management application for community oncology.

Elizabeth O'Brien, Aanshi Thumar, Melanie Manning, Krishna Gunturu, Peter Yu, Tony K W Hung

Abstract read
In one paragraph

Article in JAMIA open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Elizabeth O'BrienCancer Institute, Hartford HealthCare, Hartford, CT 06106, United States.
Aanshi ThumarCancer Institute, Hartford HealthCare, Hartford, CT 06106, United States.
Melanie ManningCancer Institute, Hartford HealthCare, Hartford, CT 06106, United States.
Krishna GunturuCancer Institute, Hartford HealthCare, Hartford, CT 06106, United States.
Peter YuCancer Institute, Hartford HealthCare, Hartford, CT 06106, United States.ORCID https://orcid.org/0000-0003-0982-923X
Tony K W HungCancer Institute, Hartford HealthCare, Hartford, CT 06106, United States.ORCID https://orcid.org/0000-0002-3872-5512

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Participation in cancer clinical trials is low in community oncology settings, partly because institution-specific trial information is fragmented. We evaluated feasibility of embedding curated trial content in an AI-enabled knowledge management application. Materials and Methods: At a regional community oncology network, coordinators and disease teams compiled actively recruiting trials. Core elements (title, conditions, biomarkers, stage/line, and recruiting status) were structured for point-of-care display and uploaded. AI-assisted extraction generated protocol summaries and eligibility elements, which underwent systematic human validation. Results: Fifty-three trials across 10 disease groups were embedded and validated; 91% were recruiting. Trials covered 28 cancer types; 30% were biomarker-specific and most enrolled advanced/metastatic disease. Initial configuration took 2-4 weeks per disease group using existing personnel, without added staffing or electronic health record (EHR) build. Discussion: Embedding institution-specific trial content within an AI-enabled knowledge application is feasible in community oncology using existing clinical and research infrastructure, establishing a prerequisite for future usability and implementation studies.

Indexed as

accrualapp developmentartificial intelligencecancer care engagementclinical trialsLookUpTrialsquality improvementuser engagement

Identifiers

PMID42488172
PMCPMC13390100

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.