Evidence mapPaperPMID 42488178Full record

ArticleMolecular therapy. Advances2026

mRNA delivery to the retina restores REP1 function in choroideremia.

Luisa de Lemos, Pedro Antas, Cláudia Carvalho, Mariana Castro, Diogo Bruno, Ana F Fonseca, Shuvajit Rakshit, Miguel C Seabra

Abstract read
In one paragraph

Article in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Luisa de LemosChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.
Pedro AntasChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.
Cláudia CarvalhoChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.
Mariana CastroINOVA4Health, NOVA Medical School (NMS), Faculdade de Ciências Médicas, Universidade Nova de Lisboa, 1169-056 Lisbon, Portugal.
Diogo BrunoChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.
Ana F FonsecaChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.
Shuvajit RakshitChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.
Miguel C SeabraChampalimaud Foundation, Champalimaud Research, 1400-038 Lisbon, Portugal.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inherited retinal diseases (IRDs) represent a major cause of blindness, yet current viral vector-based gene therapies are limited by high cost, restricted cargo capacity, and safety concerns related to immunogenicity. We explore here retinal delivery of non-viral,

Indexed as

choroideremiainherited retinal diseasesmRNA-based therapynon-viral gene therapyretinal pigment epithelium, RPE

Identifiers

PMID42488178
PMCPMC13390122

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.