ArticleCureus2026
A Rare Cause of Transaminitis: Anti-3-Hydroxy-3-Methylglutaryl-CoA Reductase Myopathy.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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3 authors.
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Abstract
Persistent transaminitis has a very broad differential diagnosis, and extrahepatic causes may often be initially overlooked. Anti-3-hydroxy-3-methylglutaryl-CoA reductase (anti-HMGCR) myopathy is a subtype of immune-mediated necrotizing myopathy (IMNM) characterized by the presence of anti-HMGCR antibodies and myofiber injury. Patients typically present with proximal extremity weakness, transaminitis, and a history of statin use. Unlike statin intolerance or statin myopathy, the weakness and biochemical abnormalities persist despite discontinuation of the drug. Here, we present a case of a patient with transaminitis and elevated creatine kinase (CK) levels, which persisted after cessation of his statin and were found to be associated with mildly elevated anti-HMGCR antibodies. Interestingly, he did not require immunosuppression for the resolution of his myopathy.
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