Evidence mapPaperPMID 42488377Full record

ArticleFrontiers in artificial intelligence2026

Beyond accuracy: evaluating the reliability of large language models for medical assessment.

Hui Zhang, Lihui Qu, Hongbo Bai, Youbang Chen, Ruiying Ji, Zirui Cheng, Chun-Tao Yang

Abstract read
In one paragraph

Article in Frontiers in artificial intelligence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hui ZhangOffice of Academic Affairs, Guangzhou Medical University, Guangzhou, China.
Lihui QuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Hongbo BaiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Youbang ChenGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Ruiying JiGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.
Zirui ChengZhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, China.
Chun-Tao YangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, Department of Physiology, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Large language models (LLMs) perform well on medical examinations, but they are almost always evaluated as test-takers, judged on the accuracy of their answers. Far less is known about their reliability as assessment-automation tools, for instance in extracting examination metadata, or about whether single-run, accuracy-based benchmarks can adequately characterize such tools. Methods: Twelve mainstream LLMs (8 domestic, 4 international) were evaluated on extracting eight metadata fields from a 60-item endocrinology examination, each performing the identical task in three independent runs under realistic web-based conditions. Performance was separated into completion rate, conditional accuracy, and an all-fields-correct task success rate (TSR), with cross-run variance treated as a primary outcome. Conditional accuracy and TSR were compared within models, and domestic versus international models were compared on TSR. Results: Conditional accuracy was uniformly high, yet TSR was sharply bimodal: five models scored 90% or above and seven below 70%, with none in between. Reliability, not mean accuracy, was decisive. Several models with perfect conditional accuracy collapsed when one or two of their three runs failed entirely, a pattern that single-run evaluation would miss. Failures spanned both model behaviour and platform-level constraints, the latter not removable by prompting. Model origin did not predict performance. On one item, four models independently changed the examiner's assigned cognitive level to one of their own, a "silent relabeling" with direct implications for item-bank integrity. Conclusion: For automated assessment metadata extraction, reliability rather than accuracy determines whether an LLM can be deployed, and national origin is not a meaningful predictor. Such tools should be evaluated by repeated runs reporting cross-run variance, and adopted through task-specific piloting within a workflow that reserves human judgement for semantic and normative fields.

Indexed as

artificial intelligenceassessment automationcross-run variancelarge language modelsmedical educationreliabilitytest blueprint

Identifiers

PMID42488377
PMCPMC13388558

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.