Evidence map›Paper›PMID 42488399›Full record

ArticleFrontiers in reproductive health2026

Understanding practices of lactation and infant feeding together with women with HIV: the UPLIFT observational study protocol.

Christiana Smith, Emily Anne Barr, Karen Hampanda, Mark Trumbull, Hulin Wu, Jennifer McKinney, Sarah Buisson, Carly Hoffmann, Ciarra Brown, Angela B Hutchinson and 9 more

Registry-linked trialAbstract read
In one paragraph

Article in Frontiers in reproductive health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07293559 (Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07293559 recruitingnot on this map

Understanding Practices of Lactation and Infant Feeding Together With Women With HIV in the United States

TypeobservationalSponsorInternational Maternal Pediatric Adolescent AIDS Clinical Trials GroupRan2026 to 2031Enrolled1,150ConditionsHIV-1-infection, Breastfeeding, Pregnancy RelatedArmsNo intervention provided in this study
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Christiana SmithDepartment of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Emily Anne BarrSchool of Nursing, University at Buffalo, Buffalo, NY, United States.
Karen HampandaDepartment of Obstetrics and Gynecology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Mark TrumbullFrontier Science & Technology Research Foundation, Amherst, NY, United States.
Hulin WuDepartment of Biostatistics & Data Science, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, United States.
Jennifer McKinneyDepartment of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Baylor College of Medicine, Houston, TX, United States.
Sarah BuissonFHI 360, Durham, NC, United States.
Carly HoffmannFrontier Science & Technology Research Foundation, Amherst, NY, United States.
Ciarra BrownThe Well Project, Brooklyn, NY, United States.
Angela B HutchinsonDivision of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States.
K Rivet AmicoUniversity of Michigan, School of Public Health, Ann Arbor, MI, United States.
Ifeyinwa V AsioduSchool of Nursing, University of California San Francisco, San Francisco, CA, United States.
Elizabeth J McFarlandDepartment of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Margaret A LampeDivision of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States.
Preetam A CholliDivision of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States.
Olga VarechtchoukDivision of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, MD, United States.
Allahna EsberMaternal and Pediatric Infectious Disease Branch, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, United States.
Athena P KourtisDivision of HIV Prevention, National Center for HIV, Hepatitis, Sexually Transmitted Diseases and Tuberculosis Prevention, Centers for Disease Control and Prevention (CDC), Department of Health and Human Services (HHS), Atlanta, GA, United States.
Lisa AbuogiDepartment of Pediatrics, Section of Infectious Diseases and Epidemiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

Funding

LOC-IMPAACT Leadership GroupPharmacokinetics and Safety of Remdesivir for Treatment of COVID-19 in Pregnant Women in the USUM1AI068632 · NIAID · SOCIAL AND SCIENTIFIC SYSTEMS, INC. · PI Jennifer Jao, Sharon A Nachman · 2011 to 2026
$278.1M
Statistical and Data Management Center-Pediatric,Adolescent, and Maternal CTGUM1AI068616 · NIAID · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI Sean Scott Brummel, Marlene Ann Cooper · 2011 to 2026
$155.6M
LC - IMPAACT Leadership GroupUM1AI106716 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Grace M Aldrovandi · 2014 to 2026
$47.2M
ACL HHS U01PS005288NCHHSTP CDC HHS U01 PS005288NIAID NIH HHS UM1 AI068616NIAID NIH HHS UM1 AI068632NIAID NIH HHS UM1 AI106716NICHD NIH HHS HHSN275201800001CNICHD NIH HHS HHSN275201800001I
6 · The paper itself

Abstract

Introduction: There is a limited understanding of infant feeding decisions, practices, and outcomes for women living with HIV (WLHIV) and their infants since U.S. guidelines were updated in 2023 to support breastfeeding for virally suppressed women on antiretroviral treatment. Methods and analysis: The Understanding Practices of Lactation and Infant Feeding Together with women with HIV (UPLIFT) study is a convergent mixed-methods, multisite, observational study designed to address key knowledge gaps. Twelve US sites will begin enrollment in early 2026 to accomplish three core activities (CA). In CA1, we explore infant feeding decision-making and experiences via in-depth interviews with pregnant/postpartum WLHIV ( Discussion: The UPLIFT study will generate critical insights to inform patient-centered care, guide practice and policy, and empower WLHIV in the US to make informed infant feeding decisions. Ethics and dissemination: The UPLIFT study received approval from Advarra, the institutional review board of record for all UPLIFT sites. Results will be disseminated through conference presentations, peer-reviewed journals, and lay summaries. Clinical Trial Registration: https://clinicaltrials.gov/study/NCT07293559, NCT07293559.

Indexed as

breastfeedingbreast milkinfant exposure to HIVinfant feedinglactationperinatal HIV transmissionpregnancywoman living with HIV

Identifiers

PMID42488399
PMCPMC13388547

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.