ArticleAmerican journal of cardiovascular disease2026
Cardioprotective effect of acupuncture in mice with diabetic cardiomyopathy by alleviating cardiac fibrosis and apoptosis.
Article in American journal of cardiovascular disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesThe purpose of this study is to assess the effects of acupuncture on glucose control, lipid metabolism, myocardial fibrosis, and the development of diabetic cardiomyopathy (DCM) in mice with type 2 diabetes.
methodsAfter modelling, mice were divided into three groups: the control, model (DCM), and PC6+ST36 group. Acupuncture was applied at PC6 and ST36 acupoints for 15 min every other day, three times a week for 8 weeks during the development of diabetic cardiomyopathy. Heart function was assessed by echocardiography and electrocardiogram. Serum glucose, lipid metabolism and ANP were assessed via ELISA. The myocardium was assessed by histology, immunoblotting, RNA-seq and CUT&Tag on the day after all the treatments were finished.
resultsAcupuncture at Neiguan and Zusanli reduced abnormal glucose (mean difference of fed glucose decrease from 19.63 mmol/L to 12.62 mmol/L,
conclusionsAcupuncture at Neiguan and Zusanli can improve heart function and myocardial hypertrophy by inhibiting cardiac apoptosis and fibrosis in mice with DCM.
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