Evidence map›Paper›PMID 42488677›Full record

ArticleFrontiers in immunology2026

Dysregulated lipid metabolites GML and GMO were associated with cytotoxic T cell function and serve as biomarkers for acute pulmonary embolism.

Tongyao Guo, Weibo Gao, Aimin Zhang, Dong Wang, Yushang Zhao, Yining Li, Zhihong Yue, Lin Pei, Mei Jia, Chen Liu and 1 more

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Tongyao Guo *Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Weibo Gao *Department of Geriatrics, China-Japan Friendship Hospital, Beijing, China.
Aimin Zhang *Department of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Dong WangApplication Support Center, Shanghai AB Sciex Analytical Instrument Trading Co., Ltd., Shanghai, China.
Yushang ZhaoDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Yining LiDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Zhihong YueDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Lin PeiDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Mei JiaDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Chen LiuDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.
Lin-Lin CaoDepartment of Clinical Laboratory, Peking University People's Hospital, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To identify serum lipid biomarkers for acute pulmonary embolism (APE) and evaluate their diagnostic value, and to investigate the impact of glycerol monolaurate (GML) and glycerol monooleate (GMO) on cytotoxic T cell function. Methods: A total of 436 subjects, including APE, healthy controls, and patients with related diseases, were enrolled. Serum samples were subjected to pseudotargeted lipidomics to screen differential lipid species. Targeted LC-MS/MS analysis was used to validate the GML and GMO levels. Flow cytometry was used to assess cytotoxic T cell markers such as granzyme B, perforin, and granulysin. Results: Pseudotargeted lipidomics identified 203 upregulated and 57 downregulated serum lipids in APE versus controls. Targeted LC-MS/MS confirmed significantly elevated serum GML and GMO in APE compared with healthy controls and other diseases. Serum GML and GMO were correlated with clinical risk stratification. ROC analyses showed high sensitivity and specificity for GML and GMO individually. Cytotoxic T cells from APE patients exhibited decreased granzyme B, perforin and granulysin. Conclusion: Elevated serum GML and GMO could serve as effective diagnostic biomarkers for APE, correlating with disease severity. They were likely to impair cytotoxic T cell function by downregulating Notch1 signaling and cytotoxic proteins, suggesting their involvement in APE pathogenesis.

Indexed as

Lipid MetabolismPulmonary EmbolismT-Lymphocytes, CytotoxicAcute DiseaseAdultAntigens, Differentiation, T-LymphocyteBiomarkersFemaleHumansLipidsMaleMiddle AgedReceptor, Notch1Signal TransductionTandem Mass SpectrometryAntigens, Differentiation, T-LymphocyteBiomarkersGNLY protein, humanLipidsReceptor, Notch1acute pulmonary embolismcytotoxic T cellsglycerolipidslipidomicsnotch1 signaling

Identifiers

PMID42488677
PMCPMC13388292

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.