Evidence map›Paper›PMID 42489106›Full record

ArticleAngewandte Chemie (International ed. in English)2026

A Comprehensive

Simon H Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T Stühlinger, Sarah E Kratzwald and 7 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Simon H RüdisserDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-1107-6196
Gabriela StadlerDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-9852-6427
Giacomo PadroniDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-1406-4449
Daria BarbashDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-5921-9803
Marco M RuckstuhlDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0009-0004-2322-3634
Nils LorzDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0009-0005-5438-9028
Christina JordanDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0009-0000-5172-8999
Sarah SkibinskiDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0009-0006-2159-6343
Timo T StühlingerDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0009-0007-7718-2016
Sarah E KratzwaldMag-Lab, Vienna, Austria.ORCID https://orcid.org/0000-0002-5293-9621
Katharina M SiessMag-Lab, Vienna, Austria.
Sven BrüschweilerMag-Lab, Vienna, Austria.ORCID https://orcid.org/0000-0003-2760-9767
Gerald PlatzerResonate Bio, Vienna, Austria.ORCID https://orcid.org/0000-0003-3466-0245
Antoine CléryDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-4550-6908
Robert KonratDepartment of Structural and Computational Biology, University of Vienna, Vienna, Austria.ORCID https://orcid.org/0000-0001-6489-4080
Frédéric H-T AllainDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0002-2131-6237
Alvar D GossertDepartment of Biology, ETH Zürich, Zürich, Switzerland.ORCID https://orcid.org/0000-0001-7732-495X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Small-molecule drug discovery relies on the identification of initial chemical starting points, or screening hits, and their subsequent optimization for potency and selectivity. Fragment-based drug discovery (FBDD), particularly through

Indexed as

Drug DiscoverySmall Molecule LibrariesFluorineHumansLigandsMagnetic Resonance SpectroscopyReceptors, G-Protein-CoupledStructure-Activity RelationshipFluorineLigandsReceptors, G-Protein-CoupledSmall Molecule Librarieschemical shielding anisotropyfragment‐based drug discoveryfragment screening librariesligand affinity

Identifiers

PMID42489106
PMCPMC13592316

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.