ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026
Prolonged systemic inflammation worsens impairments to astrocyte Ca
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionChronic neuroinflammation in Alzheimer's disease (AD) alters astrocyte physiology and neurovascular unit function. AD patients frequently experience recurrent systemic inflammatory insults from comorbid conditions, which act as "secondary-hits" believed to worsen cognitive decline. The impact of these secondary insults on astrocyte-mediated neurovascular regulation remains unknown.
methodsWe applied intravital two-photon microscopy to longitudinally investigate astrocytic Ca
resultsAD mice exhibited diminished stimulation-evoked astrocytic Ca DISCUSSION: Our findings provide the first in vivo longitudinal characterization of how secondary systemic inflammation disrupts astrocyte-mediated neurovascular regulation. The selective vulnerability of astrocytic Ca
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