Evidence map›Paper›PMID 42489267›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1.

Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Qingjian XieDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yanbo ZhuDepartment of Rehabilitation Medicine, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Wenhua JiangDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Haobo XieDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Yaojia LiDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Mengjie HuDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Kezheng LiChinese PLA General Hospital, Beijing, China.
Huan YuDepartment of Pediatrics, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Yixuan PanDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Chaoyi JiangDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Xueqin SongDepartment of Neurology and Neurological Laboratory of Hebei Province, The Second Hospital of Hebei Medical University, and Key Laboratory of Neurology (Hebei Medical University), Ministry of Education, Shijiazhuang, China.
Dongsheng FanDepartment of Neurology, Peking University Third Hospital, Beijing, China.
Binbin DengDepartment of Rehabilitation Medicine, First Affiliated Hospital of Wenzhou Medical University and Department of Neurology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID https://orcid.org/0000-0002-4058-0738

Funding

Hebei Key Laboratory of Neurology 2025L-C7Natural Science Foundation of Zhejiang Province ZCLY24H0903
6 · The paper itself

Abstract

Peripheral factors that systemically regulate amyotrophic lateral sclerosis (ALS) have remained elusive-until now. Here, by integrating population-scale epidemiology with mechanistic dissection, we identify platelet factor 4 (PF4) as the central driver of a circulating neuroprotective axis that restores proteostasis and rescues ALS. In a prospective cohort of >500 000 UK Biobank participants, platelet indices were strongly associated with ALS risk, and serum PF4 levels were significantly reduced in ALS patients. Systemic administration of recombinant PF4 in hSOD1

Indexed as

amyotrophic lateral sclerosismitophagyOPTNPF4proteostasisSOD1

Identifiers

PMID42489267
PMCPMC13393263

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.