Evidence map›Paper›PMID 42489346›Full record

ArticleJournal of diabetes investigation2026

Heat shock protein 72 attenuates atherosclerosis in apolipoprotein E-deficient mice.

Rintaro Yoshizumi, Tatsuya Kondo, Takuro Watanabe, Nobukazu Miyakawa, Sayaka Kitano, Mary Ann Suico, Miki Sato, Masaji Sakaguchi, Motoyuki Igata, Takeshi Matsumura and 3 more

Abstract read
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In one paragraph

Article in Journal of diabetes investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rintaro YoshizumiDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Kumamoto, Japan.
Tatsuya KondoDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Takuro WatanabeDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Kumamoto, Japan.
Nobukazu MiyakawaDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Sayaka KitanoDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Kumamoto, Japan.
Mary Ann SuicoDepartment of Molecular Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Miki SatoDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Masaji SakaguchiDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Motoyuki IgataDepartment of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Kumamoto, Japan.
Takeshi MatsumuraDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.
Hirofumi KaiDepartment of Diabetes, Metabolism and Endocrinology, Aso Medical Center, Aso, Japan.
Eiichi ArakiDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.ORCID https://orcid.org/0000-0002-4064-7525
Naoto KubotaDepartment of Metabolic Medicine, Faculty of Life Sciences, Kumamoto University, Kumamoto, Japan.

Funding

MEXT (Ministry of Education, Culture, Sports, Science and Technology) KAKENHI 21K08533
6 · The paper itself

Abstract

backgroundHeat shock (HS) and mild electrical stimulation (MES) induce the expression of heat shock protein 72 (HSP72), which suppresses endoplasmic reticulum stress, oxidative stress, and c-Jun N-terminal kinase (JNK) activity, thereby ameliorating pathophysiologic abnormalities associated with diabetes.

aimsThis study aims to investigate whether HS + MES influences the development of atherosclerosis.

methodsHSP72

resultsIn HSP72

conclusionsCollectively, these findings indicate that induction of HSP72 expression by HS + MES prevents atherogenesis independently of glucose homeostasis.

Indexed as

atherosclerosisHeat shock protein 72macrophage polarization

Identifiers

PMID42489346
PMCPMC13394041

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.