Evidence map›Paper›PMID 42489382›Full record

ArticleJACC. Advances2026

Cardiovascular Disease in Males With Breast Cancer: A Population-Based Cohort Study.

Anjali Chauhan, Vasily Giannakeas, Deva Thiruchelvam, Paaladinesh Thavendiranathan, Eitan Amir, Michelle B Nadler, Marie-France Savard, Husam Abdel-Qadir

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In one paragraph

Article in JACC. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anjali ChauhanDivision of Cardiology, Department of Medicine, Ted Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Faculty of Health Sciences, McMaster University, Hamilton, Ontario, Canada.
Vasily GiannakeasWomen's College Hospital, Toronto, Ontario, Canada; Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; ICES, Toronto, Ontario, Canada.
Deva ThiruchelvamICES, Toronto, Ontario, Canada.
Paaladinesh ThavendiranathanDivision of Cardiology, Department of Medicine, Ted Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada.
Eitan AmirDalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada; Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Medical Oncology & Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Michelle B NadlerPrincess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada; Division of Medical Oncology & Hematology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
Marie-France SavardDivision of Medical Oncology, Department of Medicine, The Ottawa Hospital and the University of Ottawa, Ottawa, Canada.
Husam Abdel-QadirDivision of Cardiology, Department of Medicine, Ted Rogers Program in Cardiotoxicity Prevention, Peter Munk Cardiac Centre, Toronto General Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada; Women's College Hospital, Toronto, Ontario, Canada; ICES, Toronto, Ontario, Canada. Electronic address: h.abdel.qadir@utoronto.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are scarce data on cardiovascular disease (CVD) risk in male breast cancer (BC).

objectivesThe objective of the study was to describe CVD risk in males with BC compared to females with BC and cancer-free males.

methodsPopulation-based cohort study using linked administrative databases. We identified males diagnosed with BC in Ontario, Canada (1998-2021). Male BC patients were age-matched to 3 female BC and 3 male cancer-free controls. The primary outcome was hospitalization or emergency department visits for CVD. Cause-specific mortality was a secondary outcome. Cause-specific hazards regression was used to estimate HRs associated with male BC status.

resultsWe matched 683 males with BC to 2,049 females with BC and 687 males with BC to 2,061 cancer-free males (median age 68 years [IQR: 59-77 years]). Males with BC had more prevalent pre-existing CVD and risk factors than both comparators. After adjusting for baseline characteristics, male BC was associated with a similar risk of CVD hospitalization/emergency department visits compared to female BC (HR: 1.03; 95% CI: 0.86-1.25) and cancer-free males (HR: 1.00; 95% CI: 0.84-1.19). Male BC was not associated with higher CVD mortality but was associated with higher cancer mortality relative to both comparator groups.

conclusionsMales with BC have greater baseline cardiovascular risk than females with BC and cancer-free males but no increase in future CVD hazard after adjustment. This highlights the need for prioritizing cancer treatment in males with BC, with appropriate attention to CVD risk management.

Indexed as

cardio-oncologycause-specific mortalitycompeting riskshealth administrative datapopulation-based studyrisk factors

Identifiers

PMID42489382
PMCPMC13400123

What Socratic holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.