Evidence map›Paper›PMID 42489837›Full record

ArticleMagma (New York, N.Y.)2026

Actuated dose delivery and physiological monitoring of

Drew Clements, Suphachart Leewiwatwong, Anna Costelle, Seth Lee, Andrew Dummer, David Mummy, Bastiaan Driehuys

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Magma (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Drew ClementsDepartment of Radiology, Duke University Medical Center, Box 3302, Durham, NC, 27710, USA.
Suphachart LeewiwatwongBiomedical Engineering Graduate Program, Duke University, Durham, NC, USA.
Anna CostelleMedical Physics Graduate Program, Duke University, Durham, NC, USA.
Seth LeeMedical Physics Graduate Program, Duke University, Durham, NC, USA.
Andrew DummerPolarean, Inc., Durham, NC, USA.
David MummyDepartment of Radiology, Duke University Medical Center, Box 3302, Durham, NC, 27710, USA.
Bastiaan DriehuysDepartment of Radiology, Duke University Medical Center, Box 3302, Durham, NC, 27710, USA. bastiaan.driehuys@duke.edu.ORCID http://orcid.org/0000-0002-1236-4210

Funding

Early Detection of Changes in Pulmonary Gas Exchange by Hyperpolarized Xe MRIR01HL105643 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2011 to 2026
$6.7M
Using MRI To Visualize Regional Therapy Response In Idiopathic Pulmonary FibrosisR01HL126771 · NHLBI · DUKE UNIVERSITY · PI Bastiaan Driehuys · 2015 to 2026
$6.6M
NHLBI NIH HHS R01 HL105643NHLBI NIH HHS R01HL105643NHLBI NIH HHS R01HL12677NHLBI NIH HHS R01 HL126771
6 · The paper itself

Abstract

objectiveIdentify and quantify physiological sources of variability in hyperpolarized THEORY AND

methodsA modular

resultsIn Cohort A, coaching drove subjects in 70% of tests to exhale below FRC prior to dose delivery. Reduced lung volume is known to increase membrane and RBC signals beyond healthy-reference ranges. In Cohort B, changing alveolar pressure inversely affected RBC:M; Mueller increased RBC:M by 4.4% and Valsalva decreased it by 7%. Both maneuvers reduced RBC oscillation amplitude by ~20-25% of the original amplitude.

conclusionVariations in lung inflation and alveolar pressure are significant drivers of variability in critical

Indexed as

LungLung volume measurementsMagnetic resonance imagingRepeatabilityXenon-129

Identifiers

PMID42489837
PMCPMC13404269

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.