ArticleIntensive care medicine experimental2026
The role of SDF_1α/CXCR4 axis in non-antibody mediated TRALI in cardiac surgery patients.
Article in Intensive care medicine experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAcute lung injury (ALI) after extracorporeal circulation can originate from multiple causes, including transfusion. Despite improvements in blood safety policy, transfusion-related lung injury (TRALI) continues to occur, suggesting an incomplete understanding of its pathogenesis.
objectivesTo evaluate the association between the composition of the red blood cell unit (RBC) and the onset of ALI after transfusion, defined by a ratio between partial pressure of oxygen (PaO
methodsAdults undergoing scheduled cardiac surgery at Nantes University Hospital between September 2016 and March 2021 and requiring transfusion of 1-5 RBC during surgery were included. To determine the exposure of each patient (i.e., total amount of inflammatory proteins received during transfusion), we analyzed the composition (panel of 15 proteins) of each RBC received by the participants. After stimulation of peripheral blood mononuclear cells (PBMC) with supernatant RBC (SN-RBC), NK cell cytotoxicity to pulmonary epithelial cells (Calu_3 cells) was assessed. Finally, we determined the association between SN-RBC composition, patient characteristics, and blood donation preparation methods.
resultsOver the study period, 161 patients were included, of whom 54 (33.5%) developed ALI within the first 3 days. Patients with ALI had a significantly higher median (IQR) exposure to SDF_1α than non-ALI patients 2.0 × 10
conclusionsHigh exposure to SDF_1α through transfusion may be associated with the onset of ALI following cardiac surgery. The increase in NKG2D-dependent cytotoxicity of NKG2A
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