Evidence map›Paper›PMID 42490424›Full record

ArticleScience advances2026

Dopamine D2 receptors bypass canonical signaling to directly tune NMDA receptor function and aversive learning.

Sheng Gong, Joy Adler, Ying Zhu, Charlize Szeto, Lisa Lin, Caroline Rauffenbart, Arturo Torres-Herraez, Wesley B Asher, Jonathan A Javitch, Christopher P Ford

Abstract read
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheng GongDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0009-0002-7901-401X
Joy AdlerDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0003-3557-682X
Ying ZhuDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.ORCID 0000-0002-3184-4447
Charlize SzetoBarnard College of Columbia University, New York, NY 10032, USA.ORCID 0009-0009-2072-5176
Lisa LinDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Caroline RauffenbartDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.
Arturo Torres-HerraezDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.ORCID 0000-0001-6333-5623
Wesley B AsherDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.ORCID 0000-0001-7437-218X
Jonathan A JavitchDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeons, New York, NY 10032, USA.ORCID 0000-0001-7395-2967
Christopher P FordDepartment of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, CO 80045, USA.ORCID 0000-0002-4175-2933

Funding

Structure of the Dopamine D2-Like Receptor Binding SitesR01MH054137 · NIMH · NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC · PI JAVITCH, JONATHAN A · 1995 to 2025
$12.0M
Encoding Dopamine Signals in the Mesolimbic SystemR01DA035821 · NIDA · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2013 to 2023
$3.5M
Regulation of striatal acetylcholine transmission by cholinergic interneuronsR01NS095809 · NINDS · UNIVERSITY OF COLORADO DENVER · PI FORD, CHRISTOPHER PETER · 2016 to 2024
$3.4M
Determining modes of dopamine transmissionR01NS138043 · NINDS · UNIVERSITY OF COLORADO DENVER · PI Christopher Peter Ford · 2025 to 2026
$988k
Dopaminergic modulation of NMDA receptor signaling in the Nucleus AccumbensF31DA064363 · NIDA · UNIVERSITY OF COLORADO DENVER · PI Joy Adler · 2025 to 2026
$83k
NIDA NIH HHS F31 DA064363NIDA NIH HHS R01 DA035821NIMH NIH HHS R01 MH054137NINDS NIH HHS R01 NS095809NINDS NIH HHS R01 NS138043
6 · The paper itself

Abstract

Dopamine D2 receptors (D2Rs) modulate reward learning and aversive behaviors, with dysfunction linked to addiction and psychiatric disorders. D2Rs regulate behavior through modulation of striatal glutamatergic transmission, yet how D2Rs control postsynaptic glutamate signaling remains poorly understood. Using molecular tools to selectively disrupt heteromeric interactions while preserving canonical signaling, we show that physical coupling between D2Rs and GluN2B-containing

Indexed as

LearningReceptors, Dopamine D2Receptors, N-Methyl-D-AspartateSignal TransductionAnimalsDopamineLong-Term PotentiationMedium Spiny NeuronsMiceNucleus AccumbensSynapsesSynaptic TransmissionDopamineReceptors, Dopamine D2Receptors, N-Methyl-D-Aspartate

Identifiers

PMID42490424
PMCPMC13394467

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.