ArticlePloS one2026
Lipid-modifying pharmacotherapy in diabetes mellitus: A protocol for a systematic review and network meta-analysis of randomised trials.
Article in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
12 authors.
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Abstract
introductionThe global prevalence of diabetes mellitus (DM) has risen markedly, with patients facing a substantially higher risk of atherosclerotic cardiovascular disease (ASCVD) and related mortality. Although lipid-modifying agents, including statins, fibrates, cholesterol absorption inhibitors, proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i), bromodomain and extra-terminal motif inhibitors (BETi), and adenosine triphosphate-citrate lyase inhibitors (ACLi) continue to emerge, their comparative efficacy and safety in patients with DM remain uncertain. This study aims to address this gap through a comprehensive network meta-analysis (NMA) of randomized controlled trials (RCTs) evaluating cardiovascular outcomes, lipid-modifying efficacy, and safety among these therapies. METHODS AND ANALYSIS: A systematic search will be performed in PubMed, Web of Science, Scopus, the Cochrane Central Register of Controlled Trials (CENTRAL), Embase (via Ovid), International Clinical Trials Registry Platform (ICTRP) and ClinicalTrials.gov from inception, without language or regional restrictions. Eligible studies will include parallel-design RCTs comparing monotherapy or combination therapy. The primary outcome will be cardiovascular events (composite and individual), and secondary outcomes will include cardiac biomarkers, ASCVD risk scores, lipid parameters (TC, LDL-C, HDL-C, TG) and safety outcomes. Two reviewers will independently conduct study selection, data extraction, and quality assessment using the Cochrane Risk of Bias 2 (RoB 2.0) tool, with evidence certainty evaluated via the Confidence in Network Meta-Analysis (CINeMA) framework. Data will be standardized where appropriate, and analyses, including assessment of publication bias, will be conducted using Stata 18 and R. The protocol is registered with PROSPERO, and findings will be disseminated through peer-reviewed publication. Registration: PROSPERO CRD420251163974.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.