SynthesisFrontiers in neurology
Efficacy and safety of acupuncture for chemotherapy-induced nausea and vomiting: a systematic review and meta-analysis of randomized controlled trial.
Synthesis in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
8 authors.
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Abstract
Objective: Chemotherapy-induced nausea and vomiting (CINV) represents a common and debilitating side effects in cancer patients, often compromising treatment adherence and quality of life. Current management remains suboptimal, necessitating the exploration of complementary therapies. Acupuncture, as a widely used adjunctive therapy, has been attempted for the treatment of CINV. This study aims to systematically evaluate the effect and safety of acupuncture in managing CINV. Methods: We comprehensively searched seven electronic databases (EMBASE, Cochrane Library, Web of Science, PubMed, China National Knowledge Infrastructure, VIP Chinese Science and Technology Periodicals Databas, and Wanfang) and two clinical trial registries (ClinicalTrials.gov, Chinese Clinical Trial Registry) for randomized controlled trials (RCTs) comparing acupuncture with sham acupuncture or conventional treatment for CINV. The primary outcomes included complete response rate (no vomiting episodes plus no or mild nausea), the frequency of vomiting episodes, and validated scale scores. Studies quality were assessed by using the Cochrane Risk of Bias tools.The registration number of this study is CRD420251102130. Results: 49 RCTs involving 4,133 participants were included in this study. The results demonstrated that compared with the control group, acupuncture significantly reduced the incidence of vomiting (RR = 0.583, 95% CI: 0.523-0.650), vomiting severity (MD = -0.839, 95% CI: -1.256 to -0.422) and vomiting episodes (MD = -3.704, 95% CI: -6.256 to -1.152). Additionally, acupuncture lowered the incidence of nausea (RR = 0.532, 95% CI: 0.432-0.655), and nausea severity (MD = -0.895, 95% CI: -1.273 to -0.516). The most utilized acupoints were Zusanli (ST36, Conclusion: This study confirms that acupuncture is effective as an adjunctive therapy for CINV. While future large-scale, rigorously designed RCTs are warranted to further validate these findings, the current evidence provides a robust rationale for its integration into clinical practice. Systematic review registration: The registration number of this study is CRD420251102130.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.