ArticleFrontiers in pharmacology2026
Aflatoxin B1 modulates mixture-induced neurotoxicity under multi-contaminant exposure: insights from combination modeling in SH-SY5Y cells.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The chemical exposome is increasingly implicated in neurodegenerative diseases (NDs). However, although human exposure to environmental and dietary contaminants typically occurs as complex mixtures, neurotoxicity assessments still largely focus on single compounds. This study investigated the neurotoxic interactions between aflatoxin B1 (AFB1), acrylamide (ACR), and cadmium in a neuronal cell model. Methods: SH-SY5Y cells were exposed to AFB1, ACR, and Cd Results: Individual potency ranked Cd Conclusion: Overall, these findings identify AFB1 as a key contributor to mixture-induced neurotoxicity and support the use of CISNE modelling to improve low-effect interaction analysis in food contaminant risk assessment.
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