ArticleAmerican journal of translational research2026
Effects of platelet-rich plasma-assisted arthroscopic debridement plus microfracture surgery on visual analogue scale scores and cartilage repair indicators in early-stage knee osteoarthritis.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectiveTo retrospectively analyze the clinical effects of platelet-rich plasma (PRP)-assisted knee-preserving surgery in early-stage knee osteoarthritis (KOA).
methodsSixty-nine patients with early-stage KOA were enrolled and assigned to either a PRP-assisted surgery group or a surgery-only group. The following parameters were collected: visual analogue scale (VAS) scores; serum cartilage repair markers [transforming growth factor-β1 (TGF-β1), insulin-like growth factor-1 (IGF-1), matrix metalloproteinase-13 (MMP-13)]; synovial fluid inflammation and oxidative stress markers [superoxide dismutase (SOD), nitric oxide (NO)]; knee society score (KSS score); knee joint range of motion (ROM); and adverse reactions (ARs).
resultsCompared with the surgery-only group, postoperative VAS scores, MMP-13, synovial fluid inflammatory markers, NO, and extension in the PRP-assisted surgery group were notably lower, and postoperative TGF-β1, IGF-1, SOD, KSS, flexion, internal rotation, and external rotation were notably higher. There were no significant differences in the rates of excellent/good response or overall ARs between the two groups.
conclusionPRP-assisted knee-preserving surgery significantly alleviates pain symptoms in patients with early-stage KOA, promotes cartilage repair, suppresses synovial inflammation and oxidative stress, improves knee function and knee ROM, and demonstrates good safety.
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