Evidence map›Paper›PMID 42491091›Full record

ArticleFrontiers in aging neuroscience2026

Tactile sensation moderates the association between hand dexterity and higher-level cognition in older adults with and without MCI.

Kimi Estela Kobayashi-Cuya, Ryota Sakurai, Susumu Ogawa, Hiroko Matsunaga, Keigo Hinakura, Shun Yoshikoshi, Yan Li, Maki Nishinakagawa, Hiroyuki Suzuki

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In one paragraph

Article in Frontiers in aging neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kimi Estela Kobayashi-CuyaResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Ryota SakuraiResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Susumu OgawaResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Hiroko MatsunagaResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Keigo HinakuraResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Shun YoshikoshiResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Yan LiResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.
Maki NishinakagawaDepartment of Nutrition and Dietetics, College of Nutrition, Kanto Gakuin University, Kanagawa, Japan.
Hiroyuki SuzukiResearch Team for Social Participation and Healthy Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tactile sensation and hand dexterity decline with age and are associated with later-life cognition, yet it remains unclear whether tactile sensation moderates the strength of hand motor-cognitive associations. This cross-sectional study examines whether tactile sensation moderates the association between hand dexterity and higher-level cognition (executive function and processing speed) in cognitively normal (CN) older adults and those with mild cognitive impairment (MCI), and whether moderation patterns differ between these groups. Methods: Participants were 132 community-dwelling older adults aged ≥ 60 (female = 79; mean age = 73.3 ± 5.2). MCI was defined by MMSE ≥ 24 and MoCA ≤ 25. Executive function was assessed with Trail Making Test-B (TMT-B) and letter fluency (LFT); processing speed with TMT-A, Digit Symbol, and category fluency (CFT). Hand dexterity and tactile sensation were measured using the Purdue Pegboard Test and Weinstein-Semmes monofilaments. Moderation analyses tested the interaction between dexterity and tactile sensation, adjusting for demographic and health-related covariates. Results: Tactile sensation significantly moderated the association between hand dexterity and executive function and processing speed, with stronger dexterity-cognition associations among older adults with intact tactile sensation (TMT-B Conclusion: Older adults with intact tactile sensation showed stronger hand dexterity-cognitive associations, highlighting sensorimotor integrity as relevant for early screening and functional evaluation. Stratified patterns suggest possible cognitive group differences that merit further study.

Indexed as

agingexecutive functioningfunctional assessmenthand sensorimotor functionmild cognitive impairmentmotor-cognitive integrationprocessing speed

Identifiers

PMID42491091
PMCPMC13375975

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.