ArticleAmerican journal of translational research2026
Risk warning of systemic immune-inflammation index and coagulation parameters for hospital-acquired pneumonia in patients with traumatic brain injury.
Article in American journal of translational research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the predictive value of a thromboinflammatory signature integrating the Systemic Immune-Inflammation Index (SII) and routine coagulation markers for Hospital-Acquired Pneumonia (HAP) in patients with Traumatic Brain Injury (TBI).
methodsThis retrospective study included two cohorts of patients with imaging-confirmed TBI: a development cohort (n=204) and an external validation cohort (n=80). Candidate predictors included demographic characteristics, Glasgow Coma Scale score, mechanical ventilation (MV), SII, and all routine coagulation markers, including prothrombin time (PT), activated partial thromboplastin time (APTT), international normalized ratio (INR), fibrinogen (FIB), and thrombin time (TT). Multivariable logistic regression was used to identify factors associated with HAP. Among patients who developed HAP, ventilator-associated pneumonia (VAP) was analyzed descriptively as an exploratory subgroup only.
resultsIn the development cohort, 76 of 204 patients (37.3%) developed HAP. Patients with HAP exhibited significant coagulation abnormalities, including elevated FIB. Multivariable logistic regression with collinearity diagnostics (VIF analysis) identified SII, FIB, and MV as independent predictors. The combined model demonstrated good discrimination (AUC=0.824) and maintained moderate performance in the external validation cohort (AUC=0.675).
conclusionsAdmission SII, FIB, and MV are independently associated with HAP in patients with TBI. A combined model based on these variables retained original discrimination and nomogram performance for HAP. VAP-related observations are presented only as exploratory subgroup findings.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.