Evidence map›Paper›PMID 42491196›Full record

ArticleFrontiers in cardiovascular medicine2026

The mediating effect of DHA-mediated MPV improvement on coronary artery stenosis and its prognostic value.

Wenli Wang, Changguo Ou, Jianqiu Liang, Dongliang Liang, Jiangxiong Wen, Yue Xie, Baohua Liu, Yangguang Liu, Yuli Huang, Jiandi Wu

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Wenli WangDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Changguo OuDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Jianqiu LiangDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Dongliang LiangDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Jiangxiong WenDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Yue XieDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Baohua LiuDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.
Yangguang LiuDepartment of Cardiology, The Eighth Affiliated Hospital of Southern Medical University, Foshan, China.
Yuli HuangDepartment of Cardiology, The Eighth Affiliated Hospital of Southern Medical University, Foshan, China.
Jiandi WuDepartment of Cardiology, Foshan Second People's Hospital, The Affiliated Foshan Hospital of Guangdong Pharmaceutical University, Foshan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiovascular disease (CVD) remains a leading global health threat. The high incidence of coronary artery disease (CAD) is closely associated with atherosclerotic progression, and thrombosis mediated by platelet activation is a key mechanism triggering acute coronary events and contributing to the high mortality of CAD. Omega-3 polyunsaturated fatty acids ( Methods: A total of 183 patients with coronary artery disease (CAD) and 189 controls were included. Baseline data were collected, and levels of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and arachidonic acid (AA) were measured by ultra-performance liquid chromatography-mass spectrometry. Logistic regression, Spearman correlation analysis, bootstrap mediation analysis, Kaplan-Meier survival analysis, and Cox proportional hazards regression were employed to explore the mechanisms and associations between omega-3 PUFAs, MPV, and CAD onset, coronary artery stenosis severity, and MACE. Results: Serum DHA levels were significantly lower in the CAD group than in controls ( Conclusion: DHA is associated with coronary stenosis severity, and this association is statistically consistent with partial mediation by MPV. The combined assessment of DHA and MPV optimizes risk stratification in CAD patients, providing quantitative evidence for personalized nutritional interventions with significant clinical translational value.

Indexed as

coronary artery diseasedocosahexaenoic acideicosapentaenoic acidgensini scoremajor adverse cardiovascular eventsmean platelet volumemediating effect

Identifiers

PMID42491196
PMCPMC13376254

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.