ArticleJournal of clinical tuberculosis and other mycobacterial diseases2026
Serum tuberculosis biomarkers and their association with clinical characteristics among hospitalized adults living with HIV in Uganda.
Article in Journal of clinical tuberculosis and other mycobacterial diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diagnosis of pulmonary tuberculosis (PTB) among people living with HIV (PLHIV) remains challenging, particularly in high TB/HIV burden settings. We evaluated serum biomarkers associated with active PTB and their relationship with TB-related clinical characteristics among hospitalized PLHIV in Uganda. Methods: We analysed archived serum samples from adult PLHIV ( Results: Median serum concentrations of IP-10 (19,566 pg/mL; Conclusion: IP-10, β2-microglobulin, and CRP were elevated in PLHIV with active PTB, whereas leptin levels were reduced. These biomarkers did not correlate with clinical characteristics. Our findings show that serum biomarkers may aid in identifying PTB among hospitalized PLHIV but with limited value in assessing clinical presentation. Further research is warranted to rigorously evaluate their diagnostic performance in both simple and combined biomarkers models and to evaluate their point-of-care utility for TB screening and timely treatment initiation in hospitalized PLHIV.
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