Evidence mapPaperPMID 42491402Full record

ReviewiMeta2026

Spatial omics in the AI era: Technologies, algorithmic ecosystems, biological applications, and large model perspectives.

Haoxiu Wang, Xinwang Yang, Siheng Wang, Zhe Yang, Xiuhui Yang, Yutong Yang, Zirong Li, Yuqi Ren, Qianqian Zhang, Bowen Zhao and 17 more

Abstract readReview
In one paragraph

Review in iMeta, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Haoxiu WangState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.ORCID https://orcid.org/0009-0001-4977-0968
Xinwang YangMOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science Fudan University Shanghai China.
Siheng WangWestlake University Hangzhou China.
Zhe YangGuangdong Provincial/Zhuhai Key Laboratory of IRADS Beijing Normal-Hong Kong Baptist University Zhuhai China.
Xiuhui YangMcGill University Montreal Canada.
Yutong YangCity University of Hong Kong Hong Kong China.
Zirong LiState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
Yuqi RenState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
Qianqian ZhangState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
Bowen ZhaoMcGill University Montreal Canada.
Jingming XiaoWestlake University Hangzhou China.
Yidong WangPeking University Beijing China.
Junhao DongNanyang Technological University Singapore Singapore.
Zhenhao KouState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
Jie LiState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.
Liqun YangState Key Laboratory of Resource Insects, Medical Research Institute Southwest University Chongqing China.
Erhu ZhaoState Key Laboratory of Resource Insects, Medical Research Institute Southwest University Chongqing China.
Gregory FonsecaDepartment of Medical Sciences, College of Medicine and Health Sciences Khalifa University Abu Dhabi United Arab Emirates.
Ruibang LuoThe University of Hong Kong Hong Kong China.
Mingyu YangYale University New Haven USA.ORCID https://orcid.org/0000-0003-0986-3825
Hongjuan CuiState Key Laboratory of Resource Insects, Medical Research Institute Southwest University Chongqing China.ORCID https://orcid.org/0000-0003-1178-1570
Gengjie JiaState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.ORCID https://orcid.org/0009-0001-2881-962X
Dan WangGuangdong Provincial/Zhuhai Key Laboratory of IRADS Beijing Normal-Hong Kong Baptist University Zhuhai China.ORCID https://orcid.org/0000-0003-4243-4942
Haoyang LiWestlake University Hangzhou China.ORCID https://orcid.org/0000-0003-3164-8240
Jun DingMcGill University Montreal Canada.ORCID https://orcid.org/0000-0001-5183-6885
Zhiyuan YuanMOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, MOE Frontiers Center for Brain Science Fudan University Shanghai China.ORCID https://orcid.org/0000-0002-9367-4236
Haojing ShaoState Key Laboratory of Genome and Multi-omics Technologies, Shenzhen Branch, Guangdong Laboratory of Lingnan Modern Agriculture, Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs, Agricultural Genomics Institute at Shenzhen Chinese Academy of Agricultural Sciences Shenzhen China.ORCID https://orcid.org/0000-0002-8806-197X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatial omics technologys help overcome key limitations of conventional omics approaches that lack spatial information, by providing a panoramic perspective from the molecular level to the microenvironment scale for addressing spatially resolved biological questions in life sciences. With the rapid advancement of this field, there are significant differences among technology platforms, algorithms, and research workflows, which bring three core challenges to interdisciplinary researchers: the detailed explanation of technical principles, the selection of appropriate algorithms, and the future development directions. This review systematically summarizes the technical platforms and analytical algorithms of spatial omics, compares their advantages and disadvantages in the context of specific tasks and presents application cases across multiple biological fields. It also outlines the emerging research directions and advances in large model integration. It ultimately aims to provide a reference for researchers from diverse disciplines to design and implement spatial omics studies.

Indexed as

algorithmsbiological applicationslarge modelsspatial omicstechnologies

Identifiers

PMID42491402
PMCPMC13377418

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.