ArticleFrontiers in medicine2026
Effectiveness of structured nursing interventions in reducing complication related morbidity in leukemia patients undergoing hematopoietic stem cell transplantation.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hematopoietic stem cell transplantation (HSCT) is a potentially curative treatment for leukemia but is associated with high rates of complication-related morbidity, including infections, oral mucositis, graft-vs. -host disease (GVHD), and prolonged hospitalization. Structured nursing interventions may reduce these complications, yet comprehensive prospective evidence in adult leukemia patients remains limited. Objective: This study aimed to evaluate the effectiveness of a multifaceted structured nursing intervention program in reducing complication-related morbidity among leukemia patients undergoing autologous or allogeneic HSCT. Methods: A prospective interventional study was conducted from June 2024 to June 2025 in a tertiary care bone marrow transplantation unit. A total of 106 consecutive adult leukemia patients (AML, ALL, CML, CLL) were enrolled. The structured nursing intervention included comprehensive pre-transplant education, strict infection prevention bundles, scheduled oral mucosal care, gastrointestinal and nutritional support, skin care protocols, GVHD surveillance (for allogeneic recipients), psychosocial support, and a daily structured assessment checklist. Complications were systematically monitored using standardized tools during hospitalization and up to 30 days post-transplant. Outcomes were compared before and after implementation of the intervention. Results: Following the intervention, significant reductions were observed in febrile neutropenia (from 64.2% to 37.7%, a reduction of 26.5 percentage points, Conclusion: Implementation of a structured nursing intervention program significantly reduced complication-related morbidity, shortened hospital stays, and improved clinical outcomes in leukemia patients undergoing HSCT. These findings support the routine integration of standardized, evidence-based nursing protocols in HSCT care.
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