ArticleEBioMedicine2026
Determinants of the plasma metabolome: cross-sectional and longitudinal associations over six years in the NESDA cohort.
Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe plasma metabolome represents a valuable molecular readout of a person's physiological state, yet its relation to health, stress and lifestyle remains underexplored collectively.
methodsHere, we conducted an untargeted metabolomics analysis using 3804 paired samples from 1902 participants of the observational Netherlands Study of Depression and Anxiety at baseline and six-year follow-up, quantifying 680 plasma metabolites. We characterised five metabolome principal components, three with distinct biochemical enrichments related to transmembrane transport, sphingolipid, and amino acid metabolism.
findingsMetabolite levels showed moderate intrapersonal correlation between baseline and six-year follow-up (ICC
interpretationAltogether, our study provides hierarchical insights into the cross-sectional and longitudinal implications of health, stress, and lifestyle exposures for the plasma metabolome.
fundingGeestkracht program of the Netherlands Organisation for Health Research and Development, the Dutch Research Council and the Dutch Ministry of Education, Culture and Science, Stress in Action, Amsterdam Neuroscience, ImmunoMIND, the National Institute of Mental Health, National Institute on Ageing and the Foundation for the National Institutes of Health.
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