Evidence map›Paper›PMID 42492180›Full record

ArticleEBioMedicine2026

Immunophenotype and proviral landscape of HTLV-1c infection and pulmonary disease.

Ashley Hirons, Natasha Jansz, Georges Khoury, Paula Ellenberg, Sarah Collins, James Cooney, John Zaunders, Lewis Williams, Kirthi Nandha Nair, Ashley Huey Yiing Yap and 13 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Ashley HironsDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Natasha JanszMater Research Institute - University of Queensland, TRI Building, Woolloongabba, Queensland, Australia.
Georges KhouryDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Paula EllenbergDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Sarah CollinsDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
James CooneyWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
John ZaundersNSW State Reference for HIV, Centre for Applied Medical Research, St. Vincent's Hospital, Sydney, Darlinghurst, New South Wales, Australia.
Lewis WilliamsWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Kirthi Nandha NairDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Ashley Huey Yiing YapDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Nicholas HironsUniversity of Melbourne, Victoria, Australia.
Liana MackiewiczWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Merle DaytonWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Le WangWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Daniel SijmonsDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Mohammad Radwanur TalukderDepartment of Medicine, Alice Springs Hospital, Northern Territory, Australia.
Allegra Holloway VickasDepartment of Medicine, Alice Springs Hospital, Northern Territory, Australia; Charles Darwin University, Northern Territory, Australia.
Amy W ChungDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia.
Marcel DoerflingerWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Marc PellegriniWalter and Eliza Hall Institute, Melbourne, Victoria, Australia; Department of Medical Biology, University of Melbourne, Parkville, Victoria, Australia.
Lloyd EinsiedelDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia; Department of Medicine, Alice Springs Hospital, Northern Territory, Australia. Electronic address: lloyd.einsiedel@unimelb.edu.au.
Geoffrey FaulknerMater Research Institute - University of Queensland, TRI Building, Woolloongabba, Queensland, Australia; Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia. Electronic address: faulknergj@gmail.com.
Damian F J PurcellDepartment of Microbiology and Immunology at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Victoria, Australia. Electronic address: dfjp@unimelb.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman T-lymphotropic virus 1 (HTLV-1) integrates into host DNA, resulting in life-long infection that underlies malignancy, inflammatory disease, and early all-cause mortality. HTLV-1 subtype-C endures as an endemic infection in Central Australia, and is associated with pulmonary disease. The cellular and viral features driving HTLV-1c pathogenesis remain poorly understood.

methodsWe recruited a cohort of 41 First Nations participants from Alice Springs Hospital in Central Australia. We analysed plasma biomarker sVCAM1, and three circulating CD4

findingsAll HTLV-1c+ participants showed expansion of chronically activated T

interpretationHTLV-1c likely contributes to pulmonary disease through lung-homing of chronically activated CD4

fundingThis work was supported by NHMRC, Mater Foundation, ACH4, and Miller Foundation PhD Scholarship.

Indexed as

HTLV-I InfectionsHuman T-lymphotropic virus 1ImmunophenotypingLung DiseasesProvirusesAdultAnimalsBiomarkersCD4-Positive T-LymphocytesDisease Models, AnimalFemaleHumansMaleMiceMiddle AgedViral LoadBiomarkersBronchiectasisDefective and chimeric provirusHTLV-1Lung-homing CD4+ T-cells

Identifiers

PMID42492180
PMCPMC13427564

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.