From microbubbles to macro-control: Linking ultrasound-induced microarchitecture to precise drug release kinetics from acoustically responsive scaffolds.

Haijun Xiao, Jinye Xie, Somnath Maji, Mitra Aliabouzar, Mario L Fabiilli

Abstract read

In one paragraph

Article in Ultrasonics sonochemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Haijun XiaoDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA.

Jinye XieDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA.

Somnath MajiDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA.

Mitra AliabouzarDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA; Department of Mechanical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA.

Mario L FabiilliDepartment of Radiology, University of Michigan, Ann Arbor, 48109, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, 48109, MI, USA; Applied Physics Program, University of Michigan, Ann Arbor, 48109, MI, USA. Electronic address: mfabiill@umich.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spatiotemporally controlled drug delivery systems are pivotal for advancing personalized medicine, yet programming precise release kinetics within implantable materials remains a significant challenge. Acoustically responsive scaffolds (ARSs), which utilize ultrasound to trigger payload release from phase-change emulsions embedded within a hydrogel matrix, offer a promising solution. However, the complex interplay of three ultrasound-based effects within an ARS - drug release kinetics, bubble morphology, and matrix mechanics - remains poorly understood. Here, we utilized a 2

Indexed as

Acoustic droplet vaporizationFibrinHydrogelPhase-change dropletsRelease kineticsUltrasound

Identifiers

PMID42492250

DOI10.1016/j.ultsonch.2026.107965

PMCPMC13427563

What Socratic holds

Textmetadata

LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.