ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026
Site-targeted proximal complement C3 inhibition, but not C5 blockade, attenuates neurodegeneration in a mouse model of amyotrophic lateral sclerosis: Implications for failed clinical trials.
Moumita Majumder, Davis M Borucki, Nityananda Chowdhury, Khalil Mallah, Stephen Tomlinson
Abstract read
In one paragraphArticle in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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1 · What the graph read from itWhat it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
5 authors.
Moumita MajumderDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Davis M BoruckiDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Nityananda ChowdhuryDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC, USA.
Khalil MallahDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC, USA; RalphH Johnson VA Medical Center, Charleston, SC, USA; Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, SC, USA.
Stephen TomlinsonDepartment of Pharmacology and Immunology, Medical University of South Carolina, Charleston, SC, USA; RalphH Johnson VA Medical Center, Charleston, SC, USA. Electronic address: tomlinss@musc.edu.
Funding
Translational Science Laboratory Shared ResourceP30CA138313 · NCI · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI John J Lemasters · 2009 to 2026
$42.7MThe role of SMAD1 and SATB2 in colon patterningP20GM130457 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Evan R Delgado · 2020 to 2026
$18.7MThe Role of Early Life Stress in Feeding BehaviorsP20GM148302 · NIGMS · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Jose H Ledo · 2023 to 2026
$11.5MProteomics CoreP30DK123704 · NIDDK · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI Garth R Swanson · 2020 to 2026
$8.8MConfocal/Multiphoton Microscope UpgradeS10OD018113 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI LEMASTERS, JOHN J · 2015 to 2015
$570kHigh-Content, High-Throughput Multi-Mode Imaging SystemS10OD028663 · OD · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI GOOZ, MONIKA · 2020 to 2020
$416kBLRD VA I01 BX004256BLRD VA I21 BX005853BLRD VA IK6 BX005235NCI NIH HHS P30 CA138313NIDDK NIH HHS P30 DK123704NIGMS NIH HHS P20 GM130457NIGMS NIH HHS P20 GM148302NIH HHS S10 OD018113NIH HHS S10 OD028663RRD VA I01 RX003958
6 · The paper itselfAbstract
Complement activation contributes to amyotrophic lateral sclerosis (ALS) neuropathology, but whether motor neuron degeneration is driven by proximal or terminal activation products remains unresolved. Failed trials of C5 inhibition - ravulizumab (CHAMPION-ALS) and zilucoplan (ATHLEET/HEALEY ALS Trial), and of systemic C3 inhibition (pegcetacoplan, MERIDIAN) underscore this mechanistic gap. We compared two pharmacologically distinct inhibitors in hSOD1
Indexed as
Amyotrophic Lateral SclerosisComplement C3Complement C5Nerve DegenerationAnimalsDisease Models, AnimalMiceMice, TransgenicSpinal CordComplement C3Complement C5ALSC3hSOD1(G93A)NeuroinflammationSite-targeted complement inhibition
Identifiers
PMID42492371
PMCPMC13427468
What Socratic holds
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LicenceCC BY-NC-ND
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