Evidence mapPaperPMID 42492846Full record

ReviewFrontiers in neuroendocrinology2026

Steroid 5α-reductases in the brain: From neurosteroidogenesis to therapeutic implications.

Giulia Braccagni, Caterina Branca, Marco Bortolato

Abstract readReview
In one paragraph

Review in Frontiers in neuroendocrinology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giulia BraccagniDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Caterina BrancaDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, USA.
Marco BortolatoDepartment of Cellular and Systems Pharmacology, College of Pharmacy, University of Florida, Gainesville, FL, USA. Electronic address: mbortolato@ufl.edu.

Funding

Deciphering gene-environment interactions in pathological reactive aggressionR01MH104603 · NIMH · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Marco Bortolato, Regina A. Mangieri · 2014 to 2026
$6.0M
Mechanisms of information-processing and executive deficits caused by sleep deprivationR56MH130006 · NIMH · UNIVERSITY OF UTAH · PI BORTOLATO, MARCO · 2023 to 2023
$511k
Exploring the role of neuroactive steroids in Tourette syndromeR21NS125654 · NINDS · UNIVERSITY OF UTAH · PI BORTOLATO, MARCO, COFFEY, BARBARA JANE · 2022 to 2023
$459k
NIMH NIH HHS R01 MH104603NIMH NIH HHS R56 MH130006NINDS NIH HHS R21 NS125654
6 · The paper itself

Abstract

Steroid 5α-reductases (5αRs) catalyze the irreversible, NADPH-dependent reduction of Δ

Indexed as

5α-reductaseallopregnanolonedihydrotestosteronefinasteridepost-finasteride syndromesex differencesstress

Identifiers

PMID42492846
PMCPMC13435493

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.