ArticleOsteoarthritis and cartilage2026
Does fat mass contribute to knee osteoarthritis risk beyond weight itself? Data from the Multicenter Osteoarthritis Study.
Article in Osteoarthritis and cartilage, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveWe examined the extent to which fat mass may contribute to the risk of incident radiographic knee osteoarthritis (ROA) beyond body weight alone.
methodsParticipants from the Multicenter Osteoarthritis (MOST) Study with DXA body composition and no ROA in ≥1 knee at baseline were included. Incident ROA (KL grade ≥2 or knee replacement) was assessed at 7 years. We created sex-specific weight categories (<70,70-79.9,80-89.9, ≥90 kg in females, <90,90-99.9, ≥100 kg in males), computed % fat mass quartiles, and then evaluated the relation between quartiles (lowest as referent) to risk of ROA in each weight category. We then scaled and standardized % fat mass in a combined model to assess the overall relationship between relative fat mass and ROA risk.
resultsWe included 1611 individuals (60% female, mean age 61.7 years, BMI 29.6 kg/m
conclusionsA higher relative fat mass did not influence increased risk of incident ROA in males, but there was a potential threshold effect in females. Overall, total body mass (weight) appears to be driving risk for ROA rather than a distinct influence of relative fat mass.
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