Evidence mapPaperPMID 42493601Full record

ArticleBritish journal of cancer2026

Hospital contacts before childhood cancer and the risk of early mortality: a Danish and Swedish population-based cohort study.

Line Kenborg, Hanna Mogensen, Henrik Hasle, Thomas T Nielsen, Mats Talbäck, Maria Feychting, Friederike Erdmann, Giorgio Tettamanti

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Article in British journal of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Line KenborgChildhood Cancer Research Group, Danish Cancer Institute, Copenhagen, Denmark. kenborg@cancer.dk.ORCID http://orcid.org/0000-0002-3584-6570
Hanna MogensenUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-5195-8065
Henrik HasleDepartment of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.ORCID http://orcid.org/0000-0003-3976-9231
Thomas T NielsenChildhood Cancer Research Group, Danish Cancer Institute, Copenhagen, Denmark.
Mats TalbäckUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Maria FeychtingUnit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5101-0060
Friederike Erdmann *Childhood Cancer Research Group, Danish Cancer Institute, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-9982-3300
Giorgio Tettamanti *Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5210-7219

Funding

Barncancerfonden (Swedish Childhood Cancer Foundation) PR2018-0097Forskningsrådet om Hälsa, Arbetsliv och Välfärd (Swedish Research Council for Health, Working Life and Welfare) 2019-00198
6 · The paper itself

Abstract

backgroundLimited knowledge exists on the association between hospital contacts before a childhood cancer diagnosis and the risk of early mortality.

methodsWe conducted a register-based cohort study including 14,089 children with cancer diagnosed in 1989 - 2014 in Denmark and Sweden. Odds ratios (ORs) and 95% confidence intervals (CIs) of early mortality (deaths within 0-90 days) were estimated by nights in hospital up to two years prior cancer diagnosis and diagnoses within specific main diagnostic categories using logistic regression.

resultsChildren hospitalized ≥14 nights within 2 years-14 days and 3 months-14 days before cancer diagnosis faced elevated ORs of early mortality (4.6, 95% CI 3.2-6.4; 4.4, 2.9-6.7). The association was not explained by maternal education. Early mortality was associated with diagnoses within several diagnostic categories prior to cancer diagnosis, including infectious (OR 1.5, 95% CI 1.1-2.0) and endocrine diseases (OR 1.6, 95% CI 1.02-2.5), blood (OR 3.3, 95% CI 2.1-5.1) and digestive disorders (OR 1.9, 95% CI 1.4-2.6), and symptoms with no specific diagnosis (OR 1.4, 95% CI 1.1-8).

conclusionChildren with increased time in hospital before cancer diagnosis had a higher risk for early mortality, which indicates underlying health vulnerabilities or pre-existing fragility in this population.

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.