ReviewMedScience2026
Exosome-based therapies for corneal disorders: current status and future perspectives.
Review in MedScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Exosomes, extracellular vesicles packed with diverse bioactive molecules, show significant promise as therapeutic agents for corneal disorders. This review provides an overview of the current landscape and future outlook of exosome-based therapies in ophthalmology, with a focus on corneal disease. We summarize the fundamental biology and characteristics of corneal exosomes and discuss their roles in maintaining corneal homeostasis and driving disease processes. The therapeutic potential of exosomes in corneal ulcers, dry eye disease (DED), scarring, and dystrophies is evaluated, highlighting preclinical evidence that exosomes can promote epithelial wound healing, modulate inflammation and fibrosis, and support tissue regeneration, as well as emerging clinical studies that begin to assess their safety and feasibility. We also address critical aspects of exosome isolation, characterization, engineering, and delivery strategies that are relevant for clinical translation. Despite encouraging preclinical findings, significant challenges remain, particularly in standardizing manufacturing and quality control, ensuring safety, and achieving consistent therapeutic efficacy. Future research should focus on optimizing exosome production and delivery, rationally engineering them to enhance therapeutic performance, and exploring their potential as biomarkers. Overall, exosome-based therapies hold substantial promise for transforming the management of corneal diseases, but further rigorous translational and clinical studies are required to realize their full potential.
Indexed as
Identifiers
42493709What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.