Trial reportMedical science monitor : international medical journal of experimental and clinical research2026
Effects of Single-Bout Endurance Exercise Intensity on Peripheral Neurotrophic Factors in Patients With Ischemic Stroke During the Subacute Phase of Rehabilitation.
Trial report in Medical science monitor : international medical journal of experimental and clinical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
BACKGROUND Strong evidence suggests that a single session of aerobic exercise can alter serum neurotrophin concentrations and induce neural adaptations. This study aimed to analyze the effects of exercise intensity during a single exercise session on serum neurotrophin concentrations in patients after a first ischemic stroke. MATERIAL AND METHODS Thirty participants (mean age: 65.64±9.34 years) were randomly assigned to either the low-intensity continuous exercise group (n=15) or the moderate-intensity continuous exercise group (n=15). Serum neurotrophin concentrations were measured using an enzyme-linked immunosorbent assay. Cognitive function was assessed with the Addenbrooke's Cognitive Examination III; functional ability with the Rivermead Motor Assessment; depressive symptoms with the Beck Depression Inventory; and exercise intensity with the Graded Cycling Test with the Talk Test. RESULTS Descriptively, a single session of aerobic exercise in the moderate-intensity continuous exercise group was associated with a substantial increase in serum brain-derived neurotrophic factor concentration (median change=1.9 ng/mL, 95% bootstrap confidence interval [0.7, 2.8]) and a decrease in serum irisin concentration (median change=-257.4 ng/mL, 95% bootstrap confidence interval [-490.1, -206.8]). Mean-based inferential analyses using 2-way repeated-measures analysis of variance revealed no significant Group×Time interactions for serum neurotrophins, except for lactate concentration. CONCLUSIONS A single session of aerobic exercise in patients after ischemic stroke was associated with changes in circulating lactate concentrations. Descriptive median-based analyses indicated exercise-related shifts in selected biomarkers, whereas mean-based analyses suggested broadly similar neurotrophin responses across exercise intensities.
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