Evidence map›Paper›PMID 42494135›Full record

ReviewJournal of diabetes research2026

Advances in the Identification of Novel Urinary Biomarkers for Diabetic Kidney Disease.

Yujie Jin, Yan Ma, Yan Yao, Mengru Wang, Chunchen Ni, Shujuan Shang, Yongxin Cui, Xinyu Wang, Ye Ling, Yumeng Sun and 4 more

Abstract readReview
In one paragraph

Review in Journal of diabetes research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yujie JinDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Yan MaInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Yan YaoDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Mengru WangDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Chunchen NiDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Shujuan ShangDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Yongxin CuiDepartment of Endocrinology and Genetic Metabolism, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Xinyu WangInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Ye LingInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Yumeng SunInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Qirui PeiInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Shiqiang LiuInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.
Lizhuo WangAnhui Province Key Laboratory of Basic Research and Transformation of Age-Related Diseases, Wannan Medical University, Wuhu, Anhui, China.
Jialin GaoInstitute of Endocrine and Metabolic Diseases, The First Affiliated Hospital of Wannan Medical University (Yijishan Hospital of Wannan Medical University), Wuhu, Anhui, China.ORCID https://orcid.org/0009-0009-6021-6595

Funding

Anhui Provincial Higher Education Institutions Innovation Team Project 2025AHGXZK10020China Medical Foundation 2025CMFC11Clinical Medical Research Transformation Project of Anhui Province 202527c10020017Clinical Medical Research Transformation Project of Anhui Province 202527c10020025Clinical Medical Research Transformation Project of Anhui Province 202527c10020029Clinical Medical Research Transformation Project of Anhui Province 202527c10020040Major Program of Anhui Provincial Health and Medical Research Project 2024BAC50001National Natural Science Foundation of China 82370808Yijishan Hospital 2023-3-07
6 · The paper itself

Abstract

Diabetic kidney disease (DKD) is a major microvascular complication of diabetes and remains one of the leading causes of end-stage renal disease, significantly affecting patients' survival rates and quality of life. Currently, commonly used clinical assessment indicators include proteinuria and estimated glomerular filtration rate (eGFR); however, these indicators have limited sensitivity, making it difficult to detect early kidney damage in a timely manner and to accurately monitor disease progression. This review provides a comprehensive overview of recent progress in identifying various urinary biomarkers that reflect renal tubular injury, oxidative stress, inflammatory responses, fibrotic remodeling, metabolic dysregulation, and exosomal components. Furthermore, we discuss the potential clinical applications of these biomarkers in DKD early diagnosis, disease stratification, and prognostic evaluation. Looking ahead to the future and the ongoing development of multiomics integration and artificial intelligence-assisted modeling, urinary biomarkers are expected to drive DKD diagnosis and management toward a future characterized by early detection, precision, dynamic monitoring, and noninvasive assessment.

Indexed as

BiomarkersDiabetic NephropathiesDisease ProgressionEarly DiagnosisGlomerular Filtration RateHumansOxidative StressPrognosisBiomarkersdiabetic kidney diseasenoninvasive detectionresearch progressurinary metabolic markers

Identifiers

PMID42494135
PMCPMC13396891

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.