ArticleFrontiers in neurology2026
Longitudinal changes in the ALPS index and its clinical correlates in patients with basal ganglia hemorrhage.
Article in Frontiers in neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the robustness of Diffusion Tensor Image Analysis Along the Perivascular Space (DTI-ALPS) index, and to investigate its correlation with clinical characteristics in patients following basal ganglia hemorrhage. Methods: (1) Twenty-three age- and sex-matched healthy controls were enrolled and underwent DTI scans using both 15-direction and 32-direction sequences. The differences and consistency of ALPS index between the two protocols were compared. (2) A mixed cross-sectional and longitudinal study was conducted on 56 patients. Patients were divided into three groups by time since hemorrhage: ≤ 14 days, 3 months and 1 year. The ALPS index was calculated and compared among patient groups and against healthy controls. Correlations between the ALPS index with hematoma volume and the Brunnstrom recovery stage for the hand (BRS-H) were analyzed. Results: (1) Comparison of ALPS index calculated from 15-direction and 32-direction DTI data revealed significant differences in the left hemisphere (ALPS-L) between the two protocols, while no statistically significant difference was observed in the right hemisphere (ALPS-R) and the bilateral mean (ALPS-mean). The consistency between the two protocols was excellent across all groups (ICC = 0.959-0.981, Conclusion: Basal ganglia hemorrhage is associated with impaired glymphatic function, with partial recovery after 3 months. The ALPS index showed a significant negative correlation with hematoma volume, supporting its sensitivity to hematoma-induced brain injury.
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