Evidence map›Paper›PMID 42494412›Full record

ArticleMaterials today. Bio2026

Injectable polysaccharide hydrogel microspheres integrated with BPNS-ZnO nanocomposites restore redox homeostasis and protect cartilage in osteoarthritis.

Yuqing Lei, Tao Ma, Xiaolong Lin, Yuting Sun, Chenlong Liu, Jiapei Yao, Jingwei Wu, Junyang Li, Xiaoshuang Tu, Bo Pang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yuqing LeiDepartment of Minimally Invasive Interventional Radiology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 510260, China.
Tao MaDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Xiaolong LinStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.
Yuting SunDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Chenlong LiuDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Jiapei YaoDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Jingwei WuDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Junyang LiDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Xiaoshuang TuDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Bo PangDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Zhuoyi LuDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Dong LiTrauma Center, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Ling ZhangStomatology Hospital, School of Stomatology, Zhejiang University School of Medicine, Zhejiang Provincial Clinical Research Center for Oral Diseases, Key Laboratory of Oral Biomedical Research of Zhejiang Province, Cancer Center of Zhejiang University, Engineering Research Center of Oral Biomaterials and Devices of Zhejiang Province, Hangzhou, 310000, China.
Jingjing ShangDepartment of Pharmacy, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Luming NongDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.
Xindie ZhouDepartment of Orthopedics, The Second People's Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Changzhou, 213000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is a progressive whole-joint disease driven by a persistent inflammatory-oxidative microenvironment that fuels cartilage destruction and osteochondral remodeling, while effective disease-modifying interventions remain scarce. Here, an injectable microsphere platform (HM@BPZn) is engineered by incorporating electronically coupled BPNS-ZnO hybrid nanosheets into a dual-polysaccharide network of methacrylated hyaluronic acid and gallic acid-grafted chondroitin sulfate. Interfacial electronic redistribution within the BPNS-ZnO hybrids enables active modulation of the pathological joint microenvironment. HM@BPZn suppresses reactive oxygen species accumulation and NF-κB signaling in macrophages, reducing inflammatory mediator production and promoting pro-resolving polarization. In inflamed chondrocytes, HM@BPZn activates the Keap1-Nrf2 pathway, upregulates antioxidant effectors including HO-1 and NQO1, and restores matrix homeostasis by suppressing catabolic markers while enhancing anabolic and lubrication-associated phenotypes. Transcriptomic profiling further verifies coordinated rewiring of inflammatory and antioxidant signaling networks. In an ACLT-induced OA model, intra-articular delivery of HM@BPZn markedly mitigates synovitis, preserves proteoglycan-rich cartilage, and attenuates pathological subchondral bone remodeling and osteophyte formation. These findings establish HM@BPZn as an injectable microenvironment-regulating platform for disease-modifying OA treatment.

Indexed as

Black phosphorus–ZnO hybridsCartilage protectionImmuno-redox reprogrammingInjectable microspheresMicroenvironment regulationOsteoarthritis

Identifiers

PMID42494412
PMCPMC13393546

What Socratic holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.