Evidence map›Paper›PMID 42494419›Full record

ArticleMaterials today. Bio2026

Intra-arterial delivery of FePt nanoparticles induces ferroptosis and immune infiltration to enhance radiotherapy.

Yaowei Yeh, Yuhsuan Huang, Yanshen Shan, Shangyin Wu, Hsiuyun Wang, Paosheng Hou, Yifu Chang, Wuchou Su, Helen Hw Chen, Chiajui Yen and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yaowei YehDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Yuhsuan HuangDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Yanshen ShanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Shangyin WuDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Hsiuyun WangDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Paosheng HouCenter of Applied Nanomedicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Yifu ChangDepartment of Surgery, Mercy Animal Medical Center, Kaohsiung, 813021, Taiwan.
Wuchou SuDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Helen Hw ChenDepartment of Radiation Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Chiajui YenDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.
Tsunglin TsaiDepartment of Oncology, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, 704023, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent advances in nanomedicine provide new opportunities to enhance radiotherapy and overcome tumor radioresistance. In this study, we investigated the therapeutic potential of iron-platinum nanoparticles (FePt NPs) delivered through intra-arterial (IA) administration to improve tumor targeting and therapeutic efficacy. FePt NPs significantly inhibited the proliferation of triple-negative breast cancer (TNBC) cells and enhanced radiosensitivity. Mechanistic studies demonstrated that FePt NPs induced ferroptosis characterized by lipid peroxidation (LPO), mitochondrial damage, and downregulation of GPX4, leading to the release of damage-associated molecular patterns (DAMPs), including ATP, high-mobility group box 1 (HMGB1), and calreticulin (CRT), thereby promoting ferroptosis-associated immunogenic cell death (ICD).

Indexed as

DAMPs releaseFePt nanoparticlesFerroptosisImmunogenic cell deathIntra-arterial administration

Identifiers

PMID42494419
PMCPMC13392566

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.