Associations of NLR, MLR, and (neutrophil + monocyte)/lymphocyte ratio with 30-day mortality in diabetic ICU patients with heart failure: A retrospective cohort study.

Jiazheng Chen, Yuxin Liang, Jiabei Wu, Hongli Li, Xiaoyang Wang, Feitong Qin, Zhijun Meng

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Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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7 authors.

Jiazheng ChenFifth Department of Clinical Medicine, Shanxi Medical University, Taiyuan, China.

Yuxin LiangDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan 030012, China.

Jiabei WuShanxi Medical University, Taiyuan, China.

Hongli LiDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan 030012, China.

Xiaoyang WangDepartment of Medical Technology, Shanxi Provincial People's Hospital, Shanxi Medical University, Taiyuan, China.

Feitong QinSchool of Public Health, Shanxi Medical University, Taiyuan, China.

Zhijun MengDepartment of Clinical Laboratory, Shanxi Provincial People's Hospital, Taiyuan 030012, China.

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No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Heart failure (HF) is a common complication in diabetes mellitus (DM), affecting approximately 40% of HF patients. While inflammation plays a crucial role in both conditions, the prognostic value of inflammatory markers in patients with both DM and HF remains unestablished. Objective: To examine the associations of neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and (neutrophil + monocyte)/lymphocyte ratio (NMLR) with 30-day mortality in ICU patients with both DM and HF. Methods: This retrospective cohort study analyzed 1318 patients with both HF and DM from the MIMIC-IV database. NLR, MLR, and NMLR were calculated from complete blood counts within 24 h of ICU admission. Multivariate Cox regression, restricted cubic spline analysis, and ROC curves assessed predictive performance. Results: Among 1318 patients, 239 died within 30 days. The deceased group had significantly higher median values of NLR (10.9 vs. 6.5), MLR (0.9 vs. 0.4), and NMLR (12.1 vs. 7.0) compared to survivors (all Conclusion: NLR, MLR, and NMLR are independent predictors of 30-day mortality in ICU patients with DM and HF, with MLR showing superior discriminative capacity.

Indexed as

Diabetes mellitusHeart failureMonocyte-to-lymphocyte ratioMortalityNeutrophil-to-lymphocyte ratio

Identifiers

PMID42494473

DOI10.1016/j.ijcha.2026.101977

PMCPMC13393562

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LicenceCC BY-NC-ND

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